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首页> 外文期刊>Taiwanese journal of obstetrics and gynecology >Nedaplatin use in patients with hypersensitivity reaction episodes to carboplatin
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Nedaplatin use in patients with hypersensitivity reaction episodes to carboplatin

机译：Nedaplatin用于患者对Carboplatin的过敏反应发作

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ObjectiveTo evaluate the benefits of nedaplatin treatment in patients with a history of hypersensitivity reactions to carboplatin.Materials and methodsWe retrospectively reviewed the medical records of patients with ovarian, fallopian, and peritoneal cancers and with a history of hypersensitivity to carboplatin between January 2010 and December 2016?at the Department of Gynecology in the Saitama Medical Center associated with Jichi Medical University. We studied the response rate to treatment with a nedaplatin-based regimen compared to that of a carboplatin regimen. Fisher's exact test was used to determine statistical significance.ResultsThirty-one patients with a past hypersensitivity to carboplatin were treated with nedaplatin-based regimen, while ten patients were treated with other drugs. The response rates in the nedaplatin- and non-nedaplatin-treated patient groups were 71.4% and 30.0%, respectively (P?=?0.021). Among all the patients, only one experienced hypersensitivity reaction to nedaplatin.ConclusionThe nedaplatin regimen following hypersensitivity to carboplatin was safe, feasible, and effective in achieving complete or partial response.
机译：ObjectiveTo评估NeDaplatin治疗在对Carboplatin的过敏反应历史中的患者的益处。材料和方法回顾性地审查了卵巢，输卵管和腹膜癌症患者的病史，并在2010年1月至2016年1月至12月之间对卡巴普林的过敏症史进行了过敏的历史？在与吉其医科大学有关的埼玉医疗中心妇科系。与卡铂方案的方案相比，我们研究了基于Nedaplatin的方案治疗的反应率。 Fisher的确切试验用于确定统计学意义。用基于Nedaplatin的方案治疗了对卡铂的过去过敏的患者进行了治疗，而10名患者用其他药物治疗。 Nedaplatin-和非Nedaplatin治疗的患者基团中的反应率分别为71.4％和30.0％（P？= 0.021）。在所有患者中，只有一个对Nedaplatin的过敏反应。结论Nedaplatin治疗后敏感性对卡铂的过敏，可安全，可行，有效地实现完全或部分反应。

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