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首页> 外文期刊>The FASEB Journal >Tenascin-W is a specific marker of glioma-associated blood vessels and stimulates angiogenesis in vitro
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Tenascin-W is a specific marker of glioma-associated blood vessels and stimulates angiogenesis in vitro

机译：Tenascin-W是胶质瘤相关血管的特异性标记，并在体外刺激血管生成

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The microenvironment hosting a tumor actively participates in regulating tumor cell proliferation, migration, and invasion. Among the extracellular matrix proteins enriched in the stroma of carcinomas are the tenascin family members tenascin-C and tenascin-W. Whereas tenascin-C overexpression in gliomas is known to correlate with poor prognosis, the status of tenascin-W in brain tumors has not been investigated so far. In the present study, we analyzed protein levels of tenascin-W in 38 human gliomas and found expression of tenascin-W in 80% of the tumor samples, whereas no tenascin-W could be detected in control, nontumoral brain tissues. Double immunohistochemical staining of tenascin-W and von Willebrand factor revealed that tenascin-W is localized around blood vessels, exclusively in tumor samples. In vitro, the presence of tenascin-W increased the proportion of elongated human umbilical vein endothelial cells (HUVECs) and augmented the mean speed of cell migration. Furthermore, tenascin-W triggered sprouting of HUVEC spheroids to a similar extent as the proangiogenic factor tenascin-C. In conclusion, our study identifies tenascin-W as a candidate biomarker for brain tumor angiogenesis that could be used as a molecular target for therapy irrespective of the glioma subtype.—Martina, E., Degen, M., Rüegg, C., Merlo, A., Lino, M. M., Chiquet-Ehrismann, R., Brellier, F. Tenascin-W is a specific marker of glioma-associated blood vessels and stimulates angiogenesis in vitro. neovascularization secreted glycoproteins Footnotes ?1 Present address: Department of Dermatology, Brigham and Women’s Hospital, Harvard Skin Disease Research Center, Harvard Medical School, Boston, MA 02115, USA.
机译：托管肿瘤的微环境积极参与调节肿瘤细胞增殖，迁移和侵袭。富含癌基质的细胞外基质蛋白质是Tenascin家庭成员Tenascin-C和Tenascin-W。虽然胶质瘤中的Tenascin-C过度表达众所周知，其预后差，但到目前为止还没有调查脑肿瘤中的Tenascin-W的状态。在本研究中，我们分析了38例人胶质瘤中Tenascin-W的蛋白质水平，并发现了80％的肿瘤样品中Tenascin-W的表达，而无需检测TenAscin-W，则无法对不脑组织进行控制。 Tenascin-W和Von Willebrand因子的双免疫组化染色显示，Tenascin-W在血管周围局部地定位，仅在肿瘤样本中。体外，Tenascin-W的存在增加了细长的人脐静脉内皮细胞（HUVEC）的比例，并增加了细胞迁移的平均速度。此外，Tenascin-W触发HUVEC球体的萌芽在类似的程度上作为促肾上腺素Tenascin-C。总之，我们的研究鉴定了Tenascin-W作为脑肿瘤血管生成的候选生物标志物，其可用作治疗的分子靶标无关，而无论神经胶质瘤亚型患者，E.，Degen，M.，Rüegg，C.，Merlo ，A.，Lino，MM，Chiquet-Ehrismann，R.，Brellier，F. Tenascin-W是胶质瘤相关血管的特定标记，并在体外刺激血管生成。新生血管分泌的糖蛋白脚注？1目前地址：皮肤科，Brigham和妇女医院，哈佛皮肤病研究中心，哈佛医学院，波士顿，MA 02115，USA。

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