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首页> 外文期刊>The FASEB Journal >Multiple coagulation factor deficiency protein 2 contains the ability to support stem cell self-renewal
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Multiple coagulation factor deficiency protein 2 contains the ability to support stem cell self-renewal

机译：多种凝血因子缺乏蛋白2含有支持干细胞自我更新的能力

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Defects in multiple coagulation factor deficiency protein 2 (MCFD2) are a cause of factor V and factor VIII combined deficiency type 2 (F5F8D). MCFD2 was also suggested to play an important role as an autocrine/paracrine factor in maintaining neural stem cell potential. The current work provided direct evidence that both amphibian and human MCFD2 can maintain stem cell pluripotency or stemness of rhesus monkey embryonic stem cells (rESCs) as basic fibroblast growth factor 2 (FGF-2) does. In most cases, MCFD2 had identical effects on stem cells as FGF-2. We investigated the possible mechanism of MCFD2 to support stem cell pluripotency by highlighting the effects of MCFD2 and FGF-2 on several signaling pathways in rESCs, namely MAPK, TGF-β, Wnt, and Akt, and 3 core transcriptional factors (Oct4, Nanog, and Sox2). In addition, some features of signaling pathways (MAPK and Akt), which are different from human embryonic stem cells (hESCs) and mouse embryonic stem cells (mESCs), are found in rESCs, indicating that primate ESCs have unique signaling mechanisms. These results may shed light on the biological roles of MCFD2, the conserved protein family distributed in both vertebrates and invertebrates. The ability to support stem cell self-renewal may be the general function of the conserved protein family.—Liu, H., Zhao, B., Chen, Y., You, D., Liu, R., Rong, M., Ji, W., Zheng, P., Lai, R. Multiple coagulation factor deficiency protein 2 contains the ability to support stem cell self-renewal.
机译：多种凝血因子缺陷蛋白2（MCFD2）中的缺陷是因子V和因子VIII组合缺乏2型（F5F8D）的原因。还建议MCFD2在维持神经干细胞潜力中发挥重要作用作为自分泌/旁静脉因子。目前的工作提供了直接证据，即两栖动物和人体MCFD2可以将恒河猴胚胎干细胞（Rescs）的干细胞多能性或茎保持为基本成纤维细胞生长因子2（FGF-2）。在大多数情况下，MCFD2对干细胞具有相同的效果作为FGF-2。我们研究了MCFD2通过突出MCFD2和FGF-2对RESC的几种信号通路的影响来支持干细胞多能性的可能机制，即MAPK，TGF-β，WNT和AKT和3个核心转录因子（OCT4，Nanog和SOX2）。此外，在RECS中发现了与人胚胎干细胞（HESC）和小鼠胚胎干细胞（MESCS）不同的信号传导途径（MAPK和AKT）的一些特征，表明灵长类主义ESC具有独特的信号机构。这些结果可能阐明了MCFD2的生物角色，保守的蛋白质家庭分布在脊椎动物和无脊椎动物中。支持干细胞自我更新的能力可能是保守蛋白家族的一般功能.-刘，H.，Zhao，B.，陈，Y.，You，D.，Liu，R.，Rong，M。 ，Ji，W.，Zheng，P.，Lai，R.多凝血因子缺乏蛋白2含有支持干细胞自我更新的能力。

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