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首页> 外文期刊>The Internet Journal of Oncology >Genetics Of The Salivary Gland Adenoid Cystic Carcinoma - A Brief Overview
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Genetics Of The Salivary Gland Adenoid Cystic Carcinoma - A Brief Overview

机译：唾液腺腺样囊性癌的遗传学 - 简要概述

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Adenoid cystic carcinoma (ACC) is one of the common aggressive variants of malignant salivary gland tumours. ACC is characterized by local spread, perineural infiltration, and distal metastases. Surgery with or without adjuvant radiotherapy is the treatment of choice. Inadequate molecular insights into signaling that triggers carcinogenesis and invasiveness in ACC together with no representative cell lines available for testing are major blocks to the discovery of more treatment options with better outcomes for this insidious cancer. Common tumour suppressor genes and oncogenes that are known to play essential roles in the pathogenesis of cancers in other organs are seen to be less prevalent in salivary gland cancers. Genes that take part in the carcinogenesis of ACCs are suspected to be unique. More research with goals to identify signaling mechanisms triggering in cancer genesis and spread to improve therapeutic insight is essential. In the short review article, we have tried to summarize all known genetic changes that have been studied and known to be involved in the carcinogenesis of ACC. This would save as a basis for more research to be done in this area with the objective of developing newer targets for treatment.
机译：腺样囊性癌（ACC）是恶性唾液腺肿瘤的常见侵袭性变体之一。 ACC的特征在于局部涂抹，渗滤性渗透和远端转移。没有辅助放射治疗的手术是选择的治疗方法。不充分的分子洞察力传递给信号传导，触发Acc的致癌和侵袭性以及没有可用于测试的代表性细胞系是发现更多治疗方案的主要障碍，具有这种阴险癌症的更好的结果。已知在其他器官的癌症发病机制中发挥基本作用的常见肿瘤抑制基因和腺草在唾液腺癌中观察到较少普遍。参与ACC的致癌物的基因被怀疑是独一无二的。对目标进行更多的研究来识别患有癌症成因的信号传导机制并传播以改善治疗洞察力至关重要。在短篇审查文章中，我们试图总结已经研究过的所有已知的遗传变化，并已知参与ACC的致癌作用。这将作为在该领域进行更多研究的基础，目的是开发新目标进行治疗。

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