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首页> 外文期刊>The journal of histochemistry and cytochemistry >Expression and Role of E-Cadherin, β-Catenin, and Vimentin in Human Papillomavirus–Positive and Human Papillomavirus–Negative Oropharyngeal Squamous Cell Carcinoma
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Expression and Role of E-Cadherin, β-Catenin, and Vimentin in Human Papillomavirus–Positive and Human Papillomavirus–Negative Oropharyngeal Squamous Cell Carcinoma

机译：E-cadherin，β-catenin和Vimentin在人乳头瘤病毒阳性和人乳头瘤病毒 - 阴性口咽鳞状细胞癌中的表达及作用

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Oropharyngeal squamous cell carcinoma (OPSCC) is subclassified by the World Health Organization into two different entities: human papillomavirus (HPV)-positive and HPV-negative tumors. HPV infection promotes the epithelial-to-mesenchymal transition (EMT) and transformation of keratinocyte stem cells into cancer stem cells. EMT is a crucial process in the carcinogenesis of epithelial-derived malignancies, and we aimed to study the role of its markers in OPSCC. This study consists of 202 consecutive OPSCC patients diagnosed and treated with curative intent. We examined E-cadherin, β-catenin, and vimentin expression using immunohistochemistry and compared these with tumor and patient characteristics and treatment outcome. We found that the cell-membranous expression of β-catenin was stronger in HPV-positive than in HPV-negative tumors, and it was stronger in the presence of regional metastasis. The stromal vimentin expression was stronger among HPV-positive tumors. A high E-cadherin expression was associated with tumor grade. No relationship between these markers and survival emerged. In conclusion, β-catenin and vimentin seem to play different roles in OPSCC: the former in the tumor tissue itself, and the latter in the tumor stroma. HPV infection may exploit the β-catenin and vimentin pathways in carcinogenic process. More, β-catenin may serve as a marker for the occurrence of regional metastasis:
机译：口咽鳞状细胞癌（OPSCC）由世界卫生组织将世界卫生组织分成两种不同的实体：人乳头瘤病毒（HPV） - 阳性和HPV阴性肿瘤。 HPV感染促进上皮 - 间充质转换（EMT）和角质形成细胞干细胞转化为癌症干细胞。 EMT是上皮衍生恶性肿瘤的致癌作用的重要过程，我们旨在研究其标志物在OPSCC中的作用。该研究由202名连续OPSCC患​​者组成，诊断和治疗治疗意图。我们检查了使用免疫组织化学的e-cadherin，β-catenin和Vimentin表达，并将这些与肿瘤和患者特征和治疗结果进行了比较。我们发现β-catenin的细胞膜表达在HPV阳性中比在HPV阴性肿瘤中较强，并且在区域转移存在下较强。在HPV阳性肿瘤中，基质Vimentin表达更强烈。高e-cadherin表达与肿瘤级相关。这些标志物与生存之间没有关系。总之，β-catenin和Vimentin似乎在OPSCC中发挥不同的作用：前者在肿瘤组织本身，后者在肿瘤基质中。 HPV感染可以利用致癌过程中的β-catenin和Vimentin途径。更多，β-catenin可以作为发生区域转移的标志物：

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