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首页> 外文期刊>The Journal of Veterinary Medical Science >Risk factors for low plasma thyroxine and high plasma thyroid-stimulating hormone concentrations in dogs with non-thyroidal diseases
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Risk factors for low plasma thyroxine and high plasma thyroid-stimulating hormone concentrations in dogs with non-thyroidal diseases

机译:低血浆甲状腺素和高血浆致血浆刺激激素浓度的危险因素,具有非甲状腺疾病的狗

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The aim of the current study was to identify independent risk factors for thyroid axis alterations in dogs with non-thyroidal diseases. In this retrospective cross-sectional study, data and plasma samples from 207 dogs with non-thyroidal diseases was used. The involvement of various factors (disease severity, sex, age, breed, category and duration of disease, and medication) in the alteration of plasma thyroxine (T4) or thyroid-stimulation hormone (TSH) concentrations was analyzed using multivariate logistic regression. Among the 207 dogs analyzed, 99 (47.8%) had low plasma T4 concentrations, while 45 (21.7%) had high TSH concentrations. Intact male sex [odds ratio (OR), 3.25; 1.67–6.35; P0.001], Labrador Retrievers (OR, 18.70; 2.32–151.00; P=0.006), moderate (OR, 2.39; 1.21–4.74; P=0.012) and severe diseases (OR, 6.84; 2.27–20.70; P0.001) were associated with increased risk for low plasma T4 concentrations. Meanwhile, intact male (OR, 3.93; 1.51–10.30; P=0.005), spayed female (OR, 4.22; 1.59–11.20; P=0.004), older age (OR, 2.73; 1.28–5.84; P=0.009), and Miniature Dachshunds (OR, 5.39; 2.38–12.20; P0.001) had increased risk for high plasma TSH concentrations. Disease severity had been determined as an independent risk factor for canine NTIS. In addition, sex, age and breed were also associated with thyroid axis alterations in dogs with non-thyroidal diseases.
机译:目前研究的目的是鉴定具有非甲状腺疾病的狗的甲状腺轴改变的独立风险因素。在该回顾性的横截面研究中,使用来自207只具有非甲状腺疾病的207只狗的数据和等离子体样品。使用多元逻辑回归分析各种因素(疾病严重程度,性别,年龄,疾病,疾病的疾病,类别和疾病持续时间和药物)的累积分析了血浆甲状腺素(T4)或甲状腺刺激激素(TSH)浓度的变化。在分析的207只狗中,99(47.8%)的等离子体T4浓度低,而45(21.7%)具有高TSH浓度。完整的男性性别[赔率比(或),3.25; 1.67-6.35; P <0.001],拉布拉多检索(或18.70; 2.32-151.00; P = 0.006),中等(或,2.39; 1.21-4.74; P = 0.012)和严重疾病(或6.84; 2.27-20.70; P <0.001 )与低血浆T4浓度的风险增加有关。同时,完整的雄性(或,3.93; 1.51-10.30; p = 0.005),飞过的女性(或4.22; 1.59-11.20; p = 0.004),年龄(或2.73; 1.28-5.84; p = 0.009),和微型腊肠犬(或5.39; 2.38-12.20; p <0.001)的风险增加了高血浆TSH浓度。疾病严重程度被确定为犬NTIS的独立危险因素。此外,性别,年龄和品种也与非甲状腺疾病的狗的甲状腺轴改变有关。

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