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首页> 外文期刊>The Journal of toxicological sciences >Continuous hemoperfusion relieves pulmonary fibrosis in patients with acute mild and moderate paraquat poisoning
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Continuous hemoperfusion relieves pulmonary fibrosis in patients with acute mild and moderate paraquat poisoning

机译：连续血液灌注可缓解急性温和和中等百草枯中毒患者的肺纤维化

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Acute paraquat poisoning (APP) is a serious public health problem with a high mortality rate and there is no specific antidote for APP in clinical. Early haemoperfusion (HP) treatment is effective in APP rescue. In this study, we compared the influence of routine HP and continuous HP on the survival rate and the treatment of pulmonary fibrosis in mild and moderate APP patients. Eighty-two cases of mild and moderate APP patients who were admitted to our hospital from January of 2017 to December of 2018 were selected. All patients were randomly divided into a routine haemoperfusion (HP) group (n = 40) and a continuous haemoperfusion (CHP) group (n = 42). Compared with the HP group, the 28-day survival rate of mild and moderate APP patients was elevated in the CHP group. Blood N-terminal procollagen Ш propeptide (PIIINP) levels in APP patients were positively related with paraquat (PQ) concentration ( r = 0.309, P = 0.000). There were statistically significant differences in the levels of PIIINP, Collage TypeIV (CIV), transforming growth factor-beta 1 (TGF-β1), malondialdehyde (MDA), superoxide dismutase (SOD) activity and sequential organ failure assessment (SOFA) score between the two groups both on the third and seventh days after treatment, and the treatment effect of the CHP group on pulmonary fibrosis in APP patients was better than that of the HP group. In conclusion, CHP treatment had a significant therapeutic effect on mild and moderate APP patients, which could effectively improve the survival rate and relieve pulmonary fibrosis.
机译：急性百草枯中毒（APP）是一个严重的公共卫生问题，死亡率高，临床中没有针对应用的特定解毒剂。早期痔核（HP）治疗在App Rescue中是有效的。在这项研究中，我们比较了常规HP和连续HP对轻度和中度APP患者肺纤维化的生存率和治疗的影响。选择了2017年1月至2018年12月入院的八十二个温和和中度App患者的轻度和中度APP患者。将所有患者随机分为常规血红蛋白（HP）组（n = 40）和连续痔核（CHP）基团（n = 42）。与HP组相比，在CHP组中，温和和中度APP患者的28天存活率升高。 App患者的血液N-末端ProcollagenⅣ肽（PIIINP）水平与百草枯（PQ）浓度正相关（r = 0.309，p = 0.000）。 PIIINP，拼贴式（CIV），转化生长因子-β1（TGF-β1），丙二醛（MDA），超氧化物歧化酶（SOD）活性和顺序器官失效评估（沙发）之间的统计学意义差异两组在治疗后的第三和第七天，CHP组对肺纤维化的治疗效果优于HP组。总之，CHP治疗对轻度和中度APP患者具有显着的治疗效果，可有效提高生存率和缓解肺纤维化。

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