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首页> 外文期刊>The Turkish journal of pediatrics. >Complete atrioventricular block associated with clozapine intoxication: case report
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Complete atrioventricular block associated with clozapine intoxication: case report

机译：完整的房室块与氯氮平中毒相关：案例报告

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摘要

Clozapine is one of the atypical anti-psychotic drugs used in the treatment of resistant schizophrenia. Although cardiac side-effects are rare, it has been reported that there may be development of myocarditis, dilated cardiomyopathy, postural orthostatic hypotension and prolonged QT duration. Complete atrioventricular (AV) block is characterized by the inability to transmit all of the atrial signal to the ventricles. Causes may be congenital, idiopathic or acquired which are associated with surgery, infection, or muscle disease. AV block is extremely serious and permanent pacemaker insertion is usually necessary for all patients. Complete AV block may develop due to clozapine intoxication through increase in vagal tonus, sinoatrial node (SN) and the inhibition of atrioventricular node signalling. The case presented here is of a 15-year old female patient who developed AV total cardiac block associated with the taking of clozapine in a suicide attempt.
机译：氯氮平是用于治疗抗性精神分裂症的非典型抗精神病药物之一。虽然心脏副作用是罕见的，但据报道，可能存在心肌炎，扩张心肌病，姿势过脱位的低血压和延长QT持续时间。完整的房室（AV）块的特征在于不能将所有心房信号传送到心室。原因可能是先天性，特发性或获得的，其与手术，感染或肌肉疾病有关。 AV块是极其严重的，永久的起搏器插入通常是所有患者所必需的。由于缩小阴道，鼻窦节点（Sn）的增加和房室节点信令的抑制，因此可以通过氯氮平毒害而产生完整的AV块。这里提出的案件是一个15岁的女性患者，开发了与自杀企图采取氯氮平相关的AV总心脏块。

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