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首页> 外文期刊>Thoracic cancer. >Peripheral blood telomere alterations in ground glass opacity (GGO) lesions may suggest malignancy
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Peripheral blood telomere alterations in ground glass opacity (GGO) lesions may suggest malignancy

机译：地面玻璃不透明（GGO）病变的外周血端粒改变可能表明恶性肿瘤

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A ground glass opacity (GGO) lung lesion may represent early stage adenocarcinoma, which has an excellent prognosis upon prompt surgical resection. However, GGO lesions have broad differential diagnoses, including both benign and malignant lesions. Our objective was to study telomere length and telomerase activity in patients with suspected lung cancer in which GGO was the predominant radiographic feature. Knowledge of telomere biology may help distinguish malignant from benign radiographic lesions and guide risk assessment of these lesions. Peripheral blood samples were taken from 22 patients with suspected adenocarcinoma with the GGO radiographic presentation. Multidisciplinary discussion confirmed the need for surgery in all cases. We used an age and gender-matched group without known lung disease as a control. Telomere length and aggregates were assessed by quantitative fluorescence in situ hybridization (QFISH) and quantitative PCR. Cell senescence was evaluated by senescence-associated heterochromatin foci. Subjects with GGO lesions had a higher percentage of lymphocytes with shorter telomeres (Q-FISH, P = 0.003). Furthermore, relative telomere length was also reduced among the GGO cases (qPCR, P 0.05). Increased senescence was observed in the GGO group compared to controls (P 0.001), with significant correlation between the senescence-associated heterochromatin foci and aggregate formation (r?=?-0.7 and r?=?-0.44 for cases and controls, respectively). In conclusion, patients with resectable early adenocarcinoma demonstrate abnormal telomere length and cell senescence in peripheral blood leukocytes compared to control subjects. Abnormal telomere biology in the peripheral blood may increase suspicion of early adenocarcinoma among patients with GGO lesions. ? 2019 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.
机译：磨碎的玻璃不透明度（GGO）肺病变可能代表早期腺癌，在提示外科切除时具有优异的预后。然而，GGO病变具有广泛的差异诊断，包括良性和恶性病变。我们的目的是研究涉嫌肺癌患者的端粒长度和端粒酶活性，其中GGO是主要的放射线照相特征。对端粒生物学的知识可能有助于区分恶性良性射线照相病变并对这些病变的风险评估。外周血样品从22例怀疑腺癌患者中获取GGO放射线介绍。多学科讨论证实了所有案例中对手术的需求。我们使用年龄和性别匹配的小组，没有已知的肺病作为对照。通过定量荧光原位杂交（QFISH）和定量PCR评估端粒长度和聚集体。通过衰老相关的异铬脲胶质评估细胞衰老。具有ggo病变的受试者具有较短的端粒较短淋巴细胞（Q鱼，P = 0.003）。此外，GGO病例中还减少了相对端粒长度（QPCR，P <0.05）。与对照组（P <0.001）相比，在GGO组中观察到衰老增加，衰老相关的异粒子灶和聚集体形成之间具有显着相关性（Rα=α - 0.7和r？= -0.44，分别用于和控制，分别）。总之，与对照受试者相比，可重症早期腺癌的患者展示了外周血白细胞中的异常端粒长度和细胞衰老。外周血异常的端粒生物学可能会增加GGO病变患者早期腺癌的怀疑。 ？ 2019年的作者。中国肺部肿瘤集团和约翰瓦里和儿子澳大利亚发表的胸癌

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