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首页> 外文期刊>Thoracic cancer. >Association between tooth loss and upper gastrointestinal cancer: A 30‐year follow‐up of the Linxian Dysplasia Nutrition Intervention Trial Cohort
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Association between tooth loss and upper gastrointestinal cancer: A 30‐year follow‐up of the Linxian Dysplasia Nutrition Intervention Trial Cohort

机译：牙齿损失和上胃肠癌之间的关联：临南发育不良营养干预试验队列的30年后续行动

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This prospective study investigated the association between tooth loss and upper gastrointestinal (UGI) cancer mortality in the Linxian Dysplasia Nutrition Intervention Trial Cohort. Subjects were categorized into three groups according to age at baseline. No missing teeth and less or greater than median tooth loss in each group was defined as none, moderate, and severe, respectively. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were estimated using the Cox proportional hazard model. Through 30 September 2015, 541 esophageal squamous cell carcinoma (ESCC), 284 gastric cardia carcinoma (GCC), and 77 gastric non-cardia carcinoma (GNCC) deaths occurred. In the six-year follow-up, severe tooth loss was associated with an increased risk of GCC mortality (HR 1.55, 95% CI 1.06-2.18). In the 15-year follow-up, moderate tooth loss increased the ESCC mortality risk by 58% (HR 1.58, 95% CI 1.06-2.35), while severe loss increased the GCC mortality risk by 30% (HR 1.30, 95% CI 1.03-1.64). In the 30-year follow-up, moderate tooth loss increased the risk of ESCC mortality (HR 1.34, 95% CI 1.01-1.76). In subjects aged 55 at baseline and men, moderate tooth loss had 53% and 52% higher risks of ESCC mortality (HR55 years 1.53, 95% CI 1.06-2.05; HRmen 1.52, 95% CI 1.01-2.28). No significant association was observed for GNCC in any subjects or subgroups. Moderate tooth loss increased the risk of ESCC mortality, particularly in younger subjects and men. Severe tooth loss increased the risk of GCC mortality. Future studies are needed to confirm these findings. ? 2019 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.
机译：该前瞻性研究研究了牙县发育不良营养干预试验队列牙齿损失和上胃肠道（UGI）癌死亡率之间的关联。根据基线的年龄，受试者分为三组。没有缺牙，每组中的中位牙齿损失分别定义为无，中度和严重。使用Cox比例危害模型估计危害比率（HRS）和95％置信区间（95％CIs）。到2015年9月30日，541个食道鳞状细胞癌（ESCC），284贲门癌（GCC）和77例胃非贲门癌（GNCC）死亡发生。在六年的随访中，严重的牙齿损失与GCC死亡率的风险增加有关（HR 1.55,95％CI 1.06-2.18）。在15年的随访中，中度牙齿损失将ESCC死亡率增加58％（HR 1.58,95％CI 1.06-2.35），而严重损失将GCC死亡率增加30％（HR 1.30,95％CI 1.03-1.64）。在30年的随访中，中度牙齿损失增加了ESCC死亡率的风险（HR 1.34,95％CI 1.01-1.76）。在基线和男性的55岁的受试者中，中度牙齿损失具有53％和52％的ESCC死亡风险（HR <55年1.53,95％CI 1.06-2.05; HRMEN 1.52,95％CI 1.01-2.28）。在任何受试者或亚组中，GNCC未观察到任何明显的关联。中度牙齿损失增加了ESCC死亡率的风险，特别是在较年轻的受试者和男性中。严重的牙齿损失增加了GCC死亡率的风险。需要未来的研究来确认这些发现。 ？ 2019年的作者。中国肺部肿瘤集团和约翰瓦里和儿子澳大利亚发表的胸癌

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