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Clinicopathological characteristics, diagnosis, and prognosis of pregnancy‐associated breast cancer

机译：妊娠相关乳腺癌的临床病理特征，诊断和预后

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The aim of this study was to evaluate the characteristics, diagnosis, prognosis, and effective treatment modalities of pregnancy-associated breast cancer (PABC). From 1 January 2005 to 31 December 2015, 142 patients with PABC were identified in the Cancer Institute and Hospital of Tianjin Medical University database. The clinicopathological features, treatment methods, and outcomes were retrospectively evaluated. The median age at diagnosis was 30?years. All patients presented with a palpable mass in the breast. The sensitivity of ultrasound and mammography in PABC diagnosis was 86% and 83.3%, respectively, which increased to 91.3% when a combination of mammography and ultrasound was used. The median tumor size was 5.5 cm, and 63.1% of patients had associated axillary lymph node metastases. The proportions of ER negative, PR negative and HER2 positive were 45.7%, 45.7% and 30%, respectively. The five-year overall survival (OS) and disease-free survival (DFS) rates were 76.8% and 63.5%, respectively. According to univariate analysis, T stage, N stage, and HER2 status were significant prognostic factors for OS and DFS. The time interval between the onset of the first symptom and the first meeting with a health professional was also significant for OS. Multivariate analysis showed that T stage and HER2 status were independent prognostic risk factors for OS and DFS. PABC is an aggressive form of breast cancer associated with advanced stage at diagnosis. Despite the existing difficulties in diagnosis, imaging examinations are indispensable. Early diagnosis and multidisciplinary therapy, including anti-HER2 targeted therapy, may be important to improve prognosis. ? 2019 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.
机译：本研究的目的是评估妊娠相关乳腺癌（PABC）的特征，诊断，预后和有效治疗方式。从2005年1月1日至2015年12月31日，在天津医科大学数据库癌症研究所和医院鉴定了142例PABC患者。回顾性评估临床病理特征，治疗方法和结果。诊断的中位年龄为30？年。所有患者均在乳房中呈现出可触及的肿块。 PABC诊断中超声和乳房X线照相术的敏感性分别为86％和83.3％，当使用乳房X线照射和超声的组合时，增加到91.3％。中位肿瘤大小为5.5厘米，63.1％的患者患有相关的腋窝淋巴结转移。 ER阴性，Pr阴性和HER2阳性的比例分别为45.7％，45.7％和30％。为期五年的整体生存（OS）和无病生存期（DFS）率分别为76.8％和63.5％。根据单变量分析，T阶段，N阶段和HER2状态是OS和DFS的显着预后因素。第一个症状的开始与健康专业人员的第一次会议之间的时间间隔对操作系统也很重要。多变量分析表明，T阶段和HER2状态是OS和DFS的独立预后危险因素。 PABC是一种与诊断晚期晚期相关的乳腺癌的侵略性形式。尽管存在诊断的困难，但成像检查是不可或缺的。早期诊断和多学科治疗，包括抗HER2针对性治疗，可能对改善预后可能是重要的。 ？ 2019年的作者。中国肺部肿瘤集团和约翰瓦里和儿子澳大利亚发表的胸癌

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