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Upregulation of phosphoserine phosphatase contributes to tumor progression and predicts poor prognosis in non‐small cell lung cancer patients

机译：磷酸磷酸磷酸酶的上调有助于肿瘤进展，预测非小细胞肺癌患者的预后差

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Growing evidence indicates that high phosphoserine phosphatase (PSPH) expression is associated with tumor prognosis in many types of cancers. However, the role of PSPH in non-small cell lung cancer (NSCLC) is unclear. The purpose of this study was to investigate the clinical significance of PSPH in NSCLC. One hundred forty-three patients with histologically confirmed NSCLC who underwent surgery were included. Quantitative real-time PCR and Western blot were used to assess PSPH expression in paired tumor and corresponding adjacent non-tumorous tissues. The role of PSPH in invasion and cell growth was investigated in vitro. Compared to adjacent normal lung tissues, PSPH messenger RNA and protein levels were significantly higher in NSCLC tissues, and the PSPH expression level was positively related to clinical stage, metastasis, and recurrence. High PSPH expression was predictive of poor overall survival. A549 cells transfected with small interfering-PSPH showed inhibited cell migration, invasion, and proliferation. We further demonstrated that PSPH might promote the invasive capabilities of NSCLC cells through the AKT/AMPK signaling pathway. Our results indicate that PSPH may act as a putative oncogene in NSCLC, and may be a vital molecular marker for the metastasis and proliferation of NSCLC cells by regulating the AKT/AMPK signaling pathway. ? 2019 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.
机译：日益增长的证据表明，高磷素磷酸酶（PSPH）表达与许多类型的癌症中的肿瘤预后有关。然而，PSPH在非小细胞肺癌（NSCLC）中的作用尚不清楚。本研究的目的是探讨psclc psph的临床意义。包括一百四十三名患有接受手术的组织证实NSCLC患者。定量实时PCR和Western印迹用于评估配对肿瘤和相应的相邻非肿瘤组织中的Psph表达。体外研究了PSPH对侵袭和细胞生长的作用。与相邻的正常肺组织相比，NSCLC组织中PSPH信使RNA和蛋白质水平显着较高，PSPH表达水平与临床阶段，转移和复发呈正相关。高PSPH表达预测整体存活差。用小干扰-PSPH转染的A549细胞显示出抑制细胞迁移，侵袭和增殖。我们进一步证明PSPH可以通过AKT / AMPK信号通路促进NSCLC细胞的侵入性能力。我们的结果表明，PSPH可以用作NSCLC中的推定的癌基因，并且可以通过调节AKT / AMPK信号通路来成为NSCLC细胞的转移和增殖的重要分子标记。 ？ 2019年的作者。中国肺部肿瘤集团和约翰瓦里和儿子澳大利亚发表的胸癌

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