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Assessment of non‐lobe‐specific lymph node metastasis in clinical stage IA non‐small cell lung cancer

机译：临床阶段非小细胞肺癌中非叶特异性淋巴结转移的评估

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The rationality of selective mediastinal lymph node dissection based on lobe-specific metastasis is still controversial. The correlation of lymph node metastasis in lobe-specific lymphatic drainage regions (LSDRs) and non-LSDRs has not been widely reported. The purpose of this study was to investigate the variables affecting nodal metastasis in non-LSDRs and to further evaluate the rationality of selective lymphadenectomy in clinical stage IA non-small cell lung cancer (NSCLC) patients. The clinicopathological information of 316 patients with clinical stage IA NSCLC who underwent lobectomy with systematic lymph node dissection between June 2014 and June 2018 was retrospectively collected for analysis. The overall lymph node metastasis rate was 19.3%. For 35 patients with positive LSDR lymph nodes, the non-LSDR lymph node metastasis rate was 31.4%. Only one patient (0.4%) among 281 patients with negative LSDR lymph nodes had nodal spread in non-LSDRs. Univariate analysis identified that solid consistency, worse differentiation, and positive status in LSDRs were unfavorable predictive variables of lymph node metastasis in non-LSDRs. Multivariate analysis showed that nodal metastasis in LSDRs was the only independent predictor of nodal involvement in non-LSDRs (P??0.001). For patients with clinical stage IA NSCLC, non-LSDR lymph node metastasis mainly depends on the involvement of the LSDR lymph node. Our observations may indicate the potential implications for the reasonable management of lymphadenectomy in stage IA NSCLC patients. ? 2019 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.
机译：基于叶特异性转移的选择性纵隔淋巴结解剖的合理性仍然存在争议。淋巴结转移在叶片特异性淋巴排水区（LSDRS）和非LSDRS中的相关性尚未得到广泛报道。本研究的目的是研究影响非LSDRS中节点转移的变量，并进一步评估临床阶段IA非小细胞肺癌（NSCLC）患者中选择性淋巴结切除术的合理性。回顾性收集了2014年6月至2018年6月在2018年6月至2018年6月患者的316例临床IA NSCLC患者的临床病理学信息。整体淋巴结转移率为19.3％。对于35例阳性LSDR淋巴结患者，非LSDR淋巴结转移率为31.4％。在281例阴性LSDR淋巴结患者中只有一名患者（0.4％）在非LSDRS中展开了焦点。单变量分析确定了LSDRS中的固体一致性，更差的分化和阳性状态是非LSDRS中淋巴结转移的不利预测变量。多变量分析表明，LSDRS中的节点转移是非LSDRS中唯一的Nodal受累的独立预测因子（P？<0.001）。对于临床阶段IA NSCLC患者，非LSDR淋巴结转移主要取决于LSDR淋巴结的累及。我们的观察可能表明IA NSCLC患者淋巴结切除术的合理管理潜在影响。 ？ 2019年的作者。中国肺部肿瘤集团和约翰瓦里和儿子澳大利亚发表的胸癌

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