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首页> 外文期刊>Theranostics >Noninvasive Imaging of Myocardial Inflammation in Myocarditis using 68Ga-tagged Mannosylated Human Serum Albumin Positron Emission Tomography
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Noninvasive Imaging of Myocardial Inflammation in Myocarditis using 68Ga-tagged Mannosylated Human Serum Albumin Positron Emission Tomography

机译：使用 68 Ga标记的人体血清白蛋白正电子发射断层扫描的心肌炎心肌炎心肌炎的非侵入性成像

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The diagnosis of myocarditis traditionally relies on invasive endomyocardial biopsy but none of the imaging studies so far are specific for infiltration of the inflammatory cells itself. We synthesized 68Ga-2-(p-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) mannosylated human serum albumin (MSA) by conjugating human serum albumin with mannose, followed by conjugation with NOTA and labeling it with 68Ga. The efficacy of 68Ga-NOTA-MSA positron emission tomography (PET) for imaging myocardial inflammation was tested in a rat myocarditis model. A significant number of mannose receptor-positive inflammatory cells infiltrated the myocardium in both human and rat myocarditis tissue. 68Ga-NOTA-MSA uptake was upregulated in organs of macrophage accumulation, such as liver, spleen, bone marrow and myocardium (0.32 (0.31~0.33) for normal versus 1.02 (0.86~1.06) for myocarditis (median (range), SUV); n=4~6 per group, p-value=0.01). 68Ga-NOTA-MSA uptake in the left ventricle was upregulated in myocarditis compared with normal rats (2.29 (1.42~3.40) for normal versus 4.18 (3.43~6.15) for myocarditis (median (range), average standard uptake value ratio against paraspinal muscle); n=6 per group, p-value 68Ga-NOTA-MSA uptake was significantly enhanced earlier in the evolution of myocarditis before any signs of inflammation could be seen on echocardiography. These results demonstrate the potential utility of visualizing infiltration of mannose receptor-positive macrophages with 68Ga-NOTA-MSA PET in the early diagnosis of as well as in the monitoring of treatment response of myocarditis.
机译：心肌炎的诊断传统上依赖于侵入性的子宫内膜活组织检查，但到目前为止没有成像研究是特异性的炎症细胞本身的渗透。通过缀合人的血清，我们合成 68℃-1,4,7-三缩氰酸苄基苄基-1,4,7-三芳基酸（Nota）甘露基化人血清白蛋白（MSA）与甘露糖的白蛋白，然后用Nota缀合并用 68 ga标记。在大鼠心肌炎模型中测试了对成像心肌炎症的GA-NOTA-MSA正电压分析（PET）的疗效。大量甘露糖受体阳性炎症细胞渗透在人和大鼠心肌炎组织中的心肌。 68 Ga-nota-msa摄取在巨噬细胞积累的器官上上调，例如肝脏，脾脏，骨髓和心肌（0.32（0.31〜0.33），对于心肌炎为1.02（0.86〜1.06） （中位数（范围），SUV）; N = 4〜6每组，P值= 0.01）。 68 左心室的Ga-nota-msa摄取在心肌炎中，与正常大鼠相比（2.29（1.42〜3.40）对心肌炎（3.43〜6.15）进行心肌炎（3.43〜6.15）（中位数（范围），平均标准摄取价值比对抗椎间肌的靶标; N = 6每组，P值68 GA-NOTA-MSA摄取在心肌炎的演变之前显着提高了在超声心动图中的任何炎症迹象之前。这些结果证明了在早期诊断中，在医学炎治疗响应的监测中，在早期诊断中表明了甘露糖受体阳性巨噬细胞的潜在效用常用能力与 68-sho-nota-msa宠物。

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