...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Therapeutic advances in urology. >Evaluation of influence of the UPOINT-guided multimodal therapy in men with chronic prostatitis/chronic pelvic pain syndrome on dynamic values NIH-CPSI: a prospective, controlled, comparative study
【24h】

Evaluation of influence of the UPOINT-guided multimodal therapy in men with chronic prostatitis/chronic pelvic pain syndrome on dynamic values NIH-CPSI: a prospective, controlled, comparative study

机译：慢性前列腺炎/慢性盆腔疼痛综合征在动态价值下的慢性前列腺炎/慢性盆腔疼痛综合征的影响评价NIH-CPSI：一种预期，对照，对比研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: The aim of this work was to evaluate the influence of UPOINT-guided (Urinary, Psychosocial, Organ-specific, Infection, Neurologic/systemic, Tenderness of skeletal muscles) multimodal therapy in patients with chronic prostatitis (CP)/chronic pelvic pain syndrome (CPPS) on the dynamic values of the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) score. Patients and methods: In our study we investigated 110 patients aged 26–68?years with CP/CPPS. We performed digital rectal examination (DRE), pre- and post-massage test (PPMT) urine culture, urine analysis, transrectal ultrasound investigation of prostate, antibiotic susceptibility testing. We divided the patients into the intervention group and the control group which was followed up without any therapy. For the intervention group we offered multimodal therapy based on each predominated positive phenotype. For the urinary phenotype, patients in intervention group received 10?mg alfuzosin. For organ-specific and tenderness domains, the patients of the intervention group received 63?mg Cernilton and 1?g Quercetin. For infection control, the patients of the intervention group received antimicrobial agents according to the results of the post-massage urine culture, antibiotic susceptibility testing and a high level of contamination 105?colony-forming units (CFU)/ml. Microbiological assessment of PPMT urine culture was conducted with aerobic and anaerobic methods of cultivation Results: The 110 patients had an average age of 43.9 ± 11.1?years and a median duration of symptoms of 6.21 ± 1.8?months. Of these, 11 patients did not complete the trial and therefore in quantitative terms, the distribution of patients was as follows: 54 in the intervention group and 45 in the control group. The average total NIH-CPSI score before treatment was 29.8 ± 6.1 in both groups. The mean NIH-CPSI of the pain, urinary, and quality of life (QOL) subscores before treatment was 15.1 ± 3.0, 7.4 ± 1.4 and 8.1 ± 2.1, respectively in both groups. After 6?weeks the PPMT urine culture of patients of the intervention group showed the absence or low-level contamination of microorganisms. After conducting the treatment, the mean total NIH-CPSI score in the intervention and control groups was 13.9 ± 2.8 (p = 0.025) and 29.8 ± 5.8 (p = 0.18), respectively. The average NIH-CPSI pain subscore in the intervention and control group after treatment was 6.7 ± 1.4 (p = 0.018) and 15.1 ± 2.8 (p = 0.21), respectively. The mean NIH-CPSI urinary subscore after treatment in the intervention and control group was 3.22 ± 1.07 (p = 0.045) and 7.4 ± 1.2 (p = 0.15), respectively. The average NIH-CPSI QOL subscore after treatment in the intervention and control group was 3.87 ± 1.28 (p = 0.015) and 8.1 ± 1.9 (p = 0.35). After multimodal therapy, the prevalence of different UPOINT-positive domains in the patients of both intervention groups did not exceed 14%. Conclusions: The UPOINT clinical phenotypes significantly changed after multimodal treatment, including antibiotics, phytotherapy and α-blockers in patients with CP/CPPS. This combination of treatment showed a decreasing total NIH-CPSI score and an elevation of QOL in patients.
机译：背景：这项工作的目的是评估慢性前列腺炎（CP）/慢性骨盆疼痛患者的Uneoint-Poided（尿，心理，器官特异性，感染，神经系统/全身，骨骼肌柔软）多模态治疗的影响综合征（CPPS）关于国家健康慢性前列腺炎症症症症症症（NIH-CPSI）得分的动态价值。患者和方法：在我们研究中，我们调查了110名患者26-68岁的患者，符合CP / CPP的年龄。我们进行了数字直肠检查（DRE），预按摩试验（PPMT）尿培养，尿液分析，前列腺超声检查前列腺，抗生素易感性试验。我们将患者分成干预组和对照组，随后没有任何治疗。对于干预组，我们提供了基于每个主要的阳性表型的多式峰治疗。对于泌尿表型，干预组患者获得10？Mg alfozosin。对于特定器官和柔软结构域，干预组的患者接受了63？Mg Cernilton和1？G槲皮素。对于感染控制，干预组的患者根据按摩后尿培养，抗生素敏感性测试和高水平的污染> 105？菌落形成单位（CFU）/ mL的结果接受抗微生物剂。 PPMT尿培养的微生物评估用好氧和厌氧方法进行培养结果：110名患者的平均年龄为43.9±11.1？年份和中位症状持续时间为6.21±1.8？数月。其中，11名患者未完成试验，因此在定量方面，患者的分布如下：54中的干预组和45例在对照组中。治疗前的平均NIH-CPSI评分为两组均为29.8±6.1。在治疗前的疼痛，泌尿和寿命质量（QOL）亚群的平均NIH-CPSI分别在两组中分别为15.1±3.0,7.4±1.4和8.1±2.1。 6岁以下的时间后，干预组患者的PPMT尿培养表现出微生物的缺失或低水平污染。进行治疗后，干预和对照组中的平均NIH-CPSI评分分别为13.9±2.8（p = 0.025）和29.8±5.8（p = 0.18）。治疗后干预和对照组的平均NIH-CPSI疼痛子疼痛分别为6.7±1.4（p = 0.018）和15.1±2.8（p = 0.21）。在干预和对照组中治疗后的平均NiH-CPSI尿群分别为3.22±1.07（p = 0.045）和7.4±1.2（p = 0.15）。干预和对照组治疗后的平均NIH-CPSI QOL QoL患者为3.87±1.28（P = 0.015）和8.1±1.9（P = 0.35）。多式化疗法后，两种干预组患者的不同令人满面的阳性域的患病率不超过14％。结论：多峰治疗后的Upnoint临床表型显着改变，包括CP / CPP患者抗生素，植物疗法和α-嵌体。这种治疗的组合表明，患者的NIH-CPSI总分和QoL的升高表明。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号