...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Therapeutic advances in drug safety. >Pruritus after discontinuation of cetirizine
【24h】

Pruritus after discontinuation of cetirizine

机译：停药后的瘙痒症

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Intense pruritus or itching emerging after discontinuation of cetirizine has been the subject of postmarketing reports submitted to the U.S. Food and Drug Administration (FDA), published in the medical literature, and discussed on the internet. To better understand and further investigate this adverse event, we analyzed cases of pruritus occurring after discontinuation of cetirizine in the FDA Adverse Event Reporting System (FAERS) database and medical literature. Methods: We conducted a retrospective study to identify and describe cases of pruritus occurring after discontinuation of cetirizine in the FAERS database and medical literature through April 24, 2017. Data collected from the reports included demographic information, reason for use, serious outcome, report source, duration of cetirizine use, time to onset of pruritus after cetirizine discontinuation, presence of associated urticaria, treatment for pruritus, concomitant comorbidities and medications associated with pruritus, rechallenge information, and patient outcome information. Results: We identified 146 cases of pruritus after discontinuation of cetirizine. Reporting frequency increased starting in 2008. The median patient age was 38?years ( n?=?141), ranging from 6 to 71?years, and cases were predominantly reported in females ( n?=?110). Most cases ( n?=?115) were submitted directly to the FDA from consumers or healthcare providers. The median duration of use of cetirizine prior to discontinuation was 24?months ( n?=?130), ranging from 0.3 to 172.2?months. The median time to onset of pruritus from discontinuation was 2?days ( n?=?91), ranging from 0.5 to 5?days. Of the 55 cases that reported discontinuation of cetirizine again after restarting, 54 reported pruritus recurrence. Conclusions: Our case series provided evidence of an association between the discontinuation of cetirizine and the development of pruritus. The mechanism by which cetirizine causes pruritus upon discontinuation is unknown. Patients and prescribers should have knowledge of this adverse event, given the widespread use and availability of cetirizine, and potential impact on patient quality of life.
机译：背景：在塞维利嗪停止后出现的剧烈瘙痒或瘙痒是提交给美国食品和药物管理局（FDA）的邮寄报告的主题，在医学文献中发表，并在互联网上讨论。为了更好地了解并进一步调查这种不良事件，我们分析了在FDA不良事件报告系统（陈）数据库和医学文献中停止条件后发生瘙痒症的病例。方法：我们进行了回顾性研究，以识别和描述在2017年4月24日在仙子数据库数据库和医学文献中停药后发生的瘙痒病例。从报告中收集的数据包括人口统计信息，使用原因，严重结果，报告来源，十六嗪使用的持续时间，瘙痒后的瘙痒症失败的时间停止，存在相关性荨麻疹，瘙痒治疗，伴随与瘙痒，重新检查信息和患者结果信息相关的药物。结果：在停药后，我们发现了146例瘙痒症后瘙痒症。报告频率从2008年开始增加。中位数患者年龄为38？年（n？=？141），范围从6到71岁？岁月，案例主要在女性中报道（n？=？110）。大多数情况（n？=？115）从消费者或医疗保健提供者直接提交给FDA。在停止前，依嗪的使用持续时间为24个月（n？=？130），范围为0.3至172.2？月份。从停止开始的瘙痒症的中位时间为2？天（n？=？91），范围为0.5至5？天。在重新启动后再次报告甲嘧啶再连续的55例，报告瘙痒复发。结论：我们的案例系列提供了依嗪停止和瘙痒的发展之间的关联的证据。 Cetirizine在停止后导致瘙痒的机制是未知的。鉴于西里嗪的广泛使用和可用性以及对患者生活质量的潜在影响，患者和处方都应该了解这种不良事件。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号