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首页> 外文期刊>Therapeutic advances in endocrinology and metabolism. >The association between dietary intake, lifestyle and incident symptomatic peripheral arterial disease among individuals with diabetes mellitus: insights from the Malm? Diet and Cancer study
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The association between dietary intake, lifestyle and incident symptomatic peripheral arterial disease among individuals with diabetes mellitus: insights from the Malm? Diet and Cancer study

机译：糖尿病患者饮食摄入，生活方式和事故症状外周动脉疾病之间的关联：来自麦芽的洞察力？饮食和癌症研究

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With the rising prevalence of both diabetes mellitus (DM) and peripheral arterial disease (PAD), the aim of this project was to examine the association between dietary intake and lifestyle on the risk of developing PAD among individuals with DM. The Malm? Diet and Cancer study was a prospective cohort study with baseline examinations carried out between 1991 and 1996 in Malm?, Sweden (n?=?30,446). Individuals with prevalent PAD and cardiovascular disease (prior stroke or myocardial infarction) were excluded from the study, resulting in a total study population of 1112 patients with prevalent DM. The diagnosis of incident PAD was validated and confirmed in 98% of patients. Of the 1112 individuals, 136 (12.2%) were diagnosed with PAD during a median follow up of 19.7?years (interquartile range 12.9–22.4). Kaplan–Meier analysis showed that men with DM more often developed incident PAD compared with women (cumulative incidences 15.5% and 8.9%, respectively, p?=?0.012). In Cox multivariable regression analysis, smoking (hazard ratio of 1.96, 95% confidence interval of 1.28–3.00) was associated with increased risk of PAD, and there was a trend that a higher intake of fish and shellfish (hazard ratio per additional gram per week of 0.99, 95% confidence interval of 0.99–1.00; p?=?0.051) was associated with a decreased risk of PAD. In conclusion, the present study demonstrated a trend towards a protective effect of higher intake of fish and shellfish upon incident symptomatic PAD among individuals with DM.
机译：随着糖尿病（DM）和外周动脉疾病（PAD）的患病率升高，该项目的目的是审查饮食摄入和生活方式之间的关联，从DM中的个体中发育垫的风险。麦芽？饮食和癌症研究是一项前瞻性队列研究，在1991年至1996年间在麦芽·瑞典（N？= 30,446）之间进行了基线检查。具有普遍存在的垫和心血管疾病（前卒中或心肌梗塞）的个体被排除在研究之外，导致1112例患有1112名患有普遍DM的患者。入射垫的诊断已验证并确认98％的患者。在1112个个体中，136名（12.2％）在中位于19.7的中位后被诊断为垫，30.7年（四分位数范围12.9-22.4）。 Kaplan-Meier分析表明，与女性相比，DM的男性更常见地发达了事件垫（分别为15.5％和8.9％，P？= 0.012）。在Cox多变量回归分析中，吸烟（1.96,95％的置信区间为1.28-3.00）与垫的风险增加有关，并且存在较高的鱼类和贝类摄入量（每额外兰克的危险比每周0.99,95％置信区间0.99-1.00; p？= 0.051）与垫的风险降低有关。总之，本研究表明，在患有DM的个体中发生的症状垫时，在发生症状垫时，对鱼类和贝类更高摄入的保护作用的趋势。

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