Precision medicine in adult and pediatric obesity: a clinical perspective

Eric M. Bomberg; Justin R. Ryder; Richard C. Brundage; Robert J. Straka; Claudia K. Fox; Amy C. Gross; Megan M. Oberle; Carolyn T. Bramante; Shalamar D. Sibley; Aaron S. Kelly

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Precision medicine in adult and pediatric obesity: a clinical perspective

机译：成人和儿科肥胖症的精密药：临床观点

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It remains largely unknown as to why some individuals experience substantial weight loss with obesity interventions, while others receiving these same interventions do not. Person-specific characteristics likely play a significant role in this heterogeneity in treatment response. The practice of precision medicine accounts for an individual’s genes, environment, and lifestyle when deciding upon treatment type and intensity in order to optimize benefit and minimize risk. In this review, we first discuss biopsychosocial determinants of obesity, as understanding the complexity of this disease is necessary for appreciating how difficult it is to develop individualized treatment plans. Next, we present literature on person-specific characteristics associated with, and predictive of, weight loss response to various obesity treatments including lifestyle modification, pharmacotherapy, metabolic and bariatric surgery, and medical devices. Finally, we discuss important gaps in our understanding of the causes of obesity in relation to the suboptimal treatment outcomes in certain patients, and offer solutions that may lead to the development of more effective and targeted obesity therapies.

机译：对于为什么有些人以肥胖的干预措施经历大量减肥，而其他人则没有收到这些相同的干预措施并没有。人特异性特征可能在治疗反应中的这种异质性中发挥重要作用。精密医学的做法占个人基因，环境和生活方式的决定治疗类型和强度，以优化益处并尽量减少风险。在这篇综述中，我们首先讨论肥胖的活检性决定因素，因为了解这种疾病的复杂性是为了欣赏发展个性化治疗计划的难度是多么困难。接下来，我们将文献呈现出与各种肥胖治疗相关的特定于人体特征的特征，包括生活方式改性，药物治疗，代谢和肥胖手术和医疗装置。最后，我们讨论了对我们对某些患者次优次治疗成果的肥胖原因的理解讨论了重要差距，并提供可能导致发展更有效和有针对性的肥胖疗法的解决方案。

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《Therapeutic advances in endocrinology and metabolism.》 |2019年第12期|共25页
作者
Eric M. Bomberg; Justin R. Ryder; Richard C. Brundage; Robert J. Straka; Claudia K. Fox; Amy C. Gross; Megan M. Oberle; Carolyn T. Bramante; Shalamar D. Sibley; Aaron S. Kelly;
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anti-obesity agentsbariatric surgeryobesityobesity etiologyprecision medicineweight loss;

机译：抗肥胖老年萎缩萎缩术治疗性细胞病史精确精选医学重量损失;

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1. Perspectives on Rational Drug Design and Therapy for Pediatric Precision Medicine [J] . Stocco Gabriele Current medicinal chemistry . 2018,第24期

机译：对儿科精密药物理性药物设计和治疗的透视
2. A MACHINE LEARNING APPROACH TO PRECISION MEDICINE TO DETERMINE OPTIMAL TREATMENTS FOR OVERWEIGHT AND OBESE ADULTS WITH KNEE OSTEOARTHRITIS [J] . Jiang X., Nelson A., Cleveland B., Osteoarthritis and cartilage . 2019,第Suppla1期

机译：一种精密药物测定超重和肥胖成人膝关节骨关节炎的最佳治疗方法的机器学习方法
3. Precision medicine for pediatric cancers lags behind that for adult cancers [J] . Printz Carrie Cancer: A Journal of the American Cancer Society . 2020,第2期

机译：儿科癌症的精确药物落后于成人癌症
4. Development of a series of Korean pediatric and adult head computational phantoms and application to nuclear medicine dosimetry [C] . Choonik Lee, Ae-Kyoung Lee, Hyung-do Choi, 18th Topical meeting of Radiation Protection and Shielding Division . 2014

机译：一系列韩国儿科和成人头部计算机模型的研制及其在核医学剂量学中的应用
5. Measured resting energy expenditure using a fixed function indirect calorimeter in the clinical setting as a predictor of success with weight change in an obese pediatric population. [D] . Henes, Sarah T. 2010

机译：在临床环境中使用固定功能间接量热仪测量静息能量消耗，作为肥胖儿科人群体重变化成功与否的预测指标。
6. Precision medicine in adult and pediatric obesity: a clinicalperspective [O] . Eric M. Bomberg, Justin R. Ryder, Richard C. Brundage, 2019

机译：成人和小儿肥胖症的精准医学：临床透视
7. ACC/AHA clinical competence statement on echocardiography11When citing this document, the American College of Cardiology, the American Heart Association, and the American College of Physicians–American Society of Internal Medicine would appreciate the following citation format: Quiñones MA, Douglas PS, Foster E, Gorcsan J, Lewis JF, Pearlman AS, Rychik J, Salcedo EE, Seward J, Stevenson JG, Thys DM, Weitz HH, and Zoghbi WA. ACC/AHA clinical competence statement on echocardiography: a report of the American College of Cardiology/American Heart Association/American College of Physicians–American Society of Internal Medicine Task Force on Clinical Competence (Committee on Echocardiography). J Am Coll Cardiol 2003;41:687–708.22This document was approved by the American College of Cardiology Board of Trustees in December 2002 and the American Heart Association Science Advisory and Coordinating Committee in November 2002.**Address for Reprints: This document is available on the Web sites of the American College of Cardiology (www.acc.org), the American Heart Association (www.americanheart.org), the American Society of Echocardiography (http://asecho.org), and the Society of Pediatric Echocardiography (www.sopeonline.com). Reprints of this document may be purchased for $5.00 each by calling 1-800-253-4636 or by writing to the American College of Cardiology, Resource Center, 9111 Old Georgetown Road, Bethesda, Maryland 20814-1699. A Report of the American College of Cardiology/American Heart Association/American College of Physicians–American Society of Internal Medicine Task Force on Clinical Competence Developed in Collaboration with the American Society of Echocardiography, the Society of Cardiovascular Anesthesiologists, and the Society of Pediatric Echocardiography [O] . Quiñones Miguel A, Douglas Pamela S, Foster Elyse, 2003

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Precision medicine in adult and pediatric obesity: a clinical perspective

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