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首页> 外文期刊>Disease markers >An Angiotensinogen Gene Polymorphism (rs5050) Is Associated with the Risk of Coronary Artery Aneurysm in Southern Chinese Children with Kawasaki Disease
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An Angiotensinogen Gene Polymorphism (rs5050) Is Associated with the Risk of Coronary Artery Aneurysm in Southern Chinese Children with Kawasaki Disease

机译：血管紧张素原基因多态性（RS5050）与川崎病南方患儿冠状动脉动脉瘤的风险有关

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Background. Kawasaki disease (KD) is an acute vasculitis disease that commonly causes acquired heart disease in children. Coronary artery aneurysm (CAA) is a major complication of KD. However, the pathogenesis of KD remains unclear. The results of a genome-wide association study (GWAS) showed that two functional single-nucleotide polymorphisms (SNPs; rs699AG and rs5050TG) in the angiotensinogen (AGT) gene were related to cardiovascular disease susceptibility. The purpose of our study was to estimate the relationship between the two GWAS-identified AGT gene polymorphisms and the risk of CAA in Southern Chinese children with KD. Methods. We genotyped the two AGT gene polymorphisms (rs699AG and rs5050TG) in 760 KD cases and 972 healthy controls. We used the odds ratios (ORs) and 95% confidence intervals (CIs) to estimate the degree of the associations. Results. These two AGT gene polymorphisms were not associated with a risk of KD relative to the controls, but after adjusting for sex and age, the carriers of the rs5050G allele with TG/GG vs TT had an adjusted OR=1.56, 95% CI=1.01-2.41, and P=0.044 relative to the carriers of the rs5050TT genotype. The susceptibility to CAA was more predominant in KD patients younger than 12 months old. Conclusions. Our results indicate that the AGT gene polymorphism rs5050TG may increase the risk of CAA in children with KD, especially those who are younger than 12 months. These results need to be verified by a validation study with a larger sample size.
机译：背景。川崎疾病（KD）是一种急性血管炎，通常导致儿童的心脏病。冠状动脉动脉瘤（CAA）是KD的主要复杂性。然而，KD的发病机制仍不清楚。基因组关联研究（GWAs）的结果表明，血管紧张素素（AGT）基因中的两个功能单核苷酸多态性（SNPS; RS699A> G和RS5050t> g）与心血管疾病易感性有关。我们研究的目的是估计两种GWAS鉴定的AGT基因多态性与KD南方南方儿童CAA之间的关系。方法。我们在760kD病例和972例健康对照中基因分为两种AGT基因多态性（RS699A> G和RS5050t> G）。我们使用赔率比（或）和95％的置信区间（CIS）来估计协会的程度。结果。这两种AGT基因多态性与KD相对于对照的风险无关，但在调整性和年龄后，RS5050G等位基因的载体与TG / GG VS TT的调节或= 1.56,95％CI = 1.01 -2.41和P = 0.044相对于RS5050TT基因型的载体。在12个月龄较小的KD患者中，对CAA的易感性更为占主导地位。结论。我们的结果表明，AGT基因多态性RS5050t> G可能会增加KD儿童CAA的风险，尤其是那些年龄小于12个月的人。这些结果需要通过具有更大样本大小的验证研究来验证。

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