...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Drug delivery. >Folate functionalized pH-sensitive photothermal therapy traceable hollow mesoporous silica nanoparticles as a targeted drug carrier to improve the antitumor effect of doxorubicin in the hepatoma cell line SMMC-7721
【24h】

Folate functionalized pH-sensitive photothermal therapy traceable hollow mesoporous silica nanoparticles as a targeted drug carrier to improve the antitumor effect of doxorubicin in the hepatoma cell line SMMC-7721

机译：叶酸官能化pH敏感的光热治疗可追踪的中空介孔二氧化硅纳米粒子作为靶向药物载体，以改善肝癌细胞系SMMC-7721中多柔比星的抗肿瘤作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In this paper, we prepared doxorubicin-loaded folic acid-functionalized pH-sensitive photothermal therapy (PTT) traceable hollow mesoporous silica nanoparticles (DOX-HPCF) as a drug carrier for liver cancer treatment. According to TEM characterization, hollow mesoporous silica nanoparticles (HMSN) are monodispersed spherical particles with hollow structure. In vitro drug release experiments showed that HPCF exhibited pH-sensitive release. Cell uptake experiments showed that HPCF was successfully absorbed by SMMC-7721 cells. In addition, DOX-HPCF significantly inhibited the proliferation of SMMC-7721 cells, and the near-infrared (NIR) light group showed a more obvious inhibitory effect. In vivo anti-tumor experiments showed that DOX-HPCF-assisted PTT inhibited tumor growth significantly. Therefore, HPCF is a promising photothermotherapy carrier for the treatment of liver cancer.
机译：在本文中，我们制备了加载的多柔比蛋白加载的叶酸官能化pH敏感的光热疗法（PTT）可追踪的中空介孔二氧化硅纳米颗粒（DOX-HPCF）作为肝癌治疗的药物载体。根据TEM表征，中空介孔二氧化硅纳米粒子（HMSN）是具有中空结构的单分散的球形颗粒。体外药物释放实验表明，HPCF表现出pH敏感的释放。细胞吸收实验表明，HPCF通过SMMC-7721细胞成功吸收。此外，DOX-HPCF显着抑制SMMC-7721细胞的增殖，近红外（NIR）光组显示出更明显的抑制作用。体内抗肿瘤实验表明，DOX-HPCF辅助PTT显着抑制肿瘤生长。因此，HPCF是一种有前途的光热疗载体，用于治疗肝癌。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号