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首页> 外文期刊>Drug Design, Development and Therapy >Beneficial Effect of Genistein on Diabetes-Induced Brain Damage in the ob/ob Mouse Model
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Beneficial Effect of Genistein on Diabetes-Induced Brain Damage in the ob/ob Mouse Model

机译：Genistein对OB / OB小鼠模型中糖尿病诱导脑损伤的有益效果

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Purpose: Diabetes mellitus (DM)-induced brain damage is characterized by cellular, molecular and functional changes. The mechanisms include oxidative stress, neuroinflammation, reduction of neurotrophic factors, insulin resistance, excessive amyloid beta (Aβ) deposition and Tau phosphorylation. Both antidiabetic and neuroprotective effects of the phytoestrogen genistein have been reported. However, the beneficial effect of genistein in brain of the ob/ob mouse model of severe obesity and diabetes remains to be determined. Methods: In this study, female ob/ob mice and lean control mice were fed with either a standard diet or a diet containing genistein (600mg/kg) for a period of 4 weeks. Body weight was monitored weekly. Blood was collected for the measurement of glucose, insulin and common cytokines. Mice brains were isolated for Western immunoblotting analyses. Results: Treatment with genistein reduced weight gain of ob/ob mice and decreased hyperglycemia compared to ob/ob mice fed the standard diet. The main findings show that genistein treatment increased insulin sensitivity and the expression levels of the neurotrophic factors nerve growth factor (NGF) and brain-derived neurotrophic factors (BDNF). In these mice, genistein also reduced Aβ deposition and the level of hyper-phosphorylated Tau protein. Conclusion: The results of our study indicate the beneficial effects of genistein in the obese?diabetic mouse?brain, including improving brain insulin signaling, increasing neurotrophic support, and alleviating Alzheimer’s disease-related pathology.
机译：目的：糖尿病（DM）诱导的脑损伤的特征在于细胞，分子和功能变化。该机制包括氧化应激，神经引发，神经营养因子的降低，胰岛素抵抗，过量淀粉样蛋白β（Aβ）沉积和Tau磷酸化。据报道，植物雌激素Genistein的抗糖尿病和神经保护作用。然而，Genistein在脑脑中的严重肥胖和糖尿病患者脑脑中的有益效果仍有待确定。方法：在本研究中，将雌性OB / OB小鼠和瘦对照小鼠用标准饮食或含有Genistein（600mg / kg）的饮食喂养4周。每周监测体重。收集血液以测量葡萄糖，胰岛素和常见细胞因子。为西免疫印迹分析分离出小鼠脑。结果：与喂养标准饮食的OB / OB小鼠相比，Genistein的重量增长和低血糖减少的治疗。主要研究结果表明，Genistein治疗增加了胰岛素敏感性和神经营养因子神经生长因子（NGF）和脑衍生的神经营养因子（BDNF）的表达水平。在这些小鼠中，Genistein也降低了Aβ沉积和高磷酸化Tau蛋白的水平。结论：我们的研究结果表明了Genistein在肥胖症中的有益效果？糖尿病小鼠？脑，包括改善脑胰岛素信号，增加神经营养载体，并减轻阿尔茨海默病相关病理学。

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