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首页> 外文期刊>Drug Design, Development and Therapy >The Climate is Changing for Metered-Dose Inhalers and Action is Needed
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The Climate is Changing for Metered-Dose Inhalers and Action is Needed

机译：对于计量剂量吸入器和所需的行动，气候正在发生变化

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Increases in global temperature are already having a significant impact on our climate. The hydrofluorocarbon (HFC) propellants used today in pressurized metered-dose inhalers (pMDIs) have global warming potential (GWP) many times that of carbon dioxide. Their use, together with all other emissive uses of HFCs, is being phased down under the Montreal protocol. This has prompted calls to switch patients to dry powder inhalers (DPIs). This paper presents a new analysis of the top 15 respiratory drug markets by drug class. It shows that a switch to DPIs would be economically feasible for most countries and most drugs. However, a wholesale switch of reliever medications, notably short-acting β-agonists, would lead to significant increases in the cost of these life-saving medications. Reviewing the evidence, whilst most patients are capable of using DPIs, the very young, very old and those undergoing an acute exacerbation still require a pMDI. Thus, there is a clinical and economic need to have both pMDIs and DPIs available. At the same time, it is projected that the reduction in non-medical uses of propellants is likely to give rise to a 5-fold increase in their cost for pMDI uses and is likely to hit the Western world in 2025. This may lead to a price increase in reliever medication that will make it unaffordable for the poorer communities in some markets. At the same time, opportunities to save money by developing new formulations using propellants with lower GWP, such as HFC 152a or HFO 1234ze(E), are described. Two companies have made this commitment, but neither currently have a strong presence in reliever medication. For them, or other companies, now is the time to act; 2025 is not far away in terms of product development timescales and the climate cannot wait.
机译：全球温度的增加已经对我们的气候产生了重大影响。今天在加压计量吸入器（PMDIS）中使用的氢氟碳（HFC）推进剂具有多次二氧化碳的全球变暖潜力（GWP）。他们的使用以及所有其他发射用途的HFCS，正在蒙特利尔议定书下逐步逐步逐步逐步逐步逐步逐步逐步逐步逐步逐步逐步逐步下降。这促使呼叫将患者转换为干粉吸入器（DPI）。本文提出了对药品课前15名呼吸系统药物的新分析。它表明，对于大多数国家和大多数药物，交换机将在经济上可行。然而，释放药物的批发交换机，特别是短作用β-激动剂，将导致这些拯救药物的成本显着增加。审查证据，而大多数患者能够使用DPI，非常年轻，非常旧的，经历急性加剧的人仍需要PMDI。因此，临床和经济需要具有PMDIS和DPI。与此同时，预计推进剂的非医疗用途减少可能会导致其对PMDI的成本增加5倍，并且可能会在2025年袭击西方世界。这可能会导致救济药物的价格增加，这将使一些市场中较贫穷的社区无法实现。同时，描述了使用具有下GWP的推进剂的新配方来节省资金的机会，例如HFC 152a或hfo 1234ze（e）。两家公司已经做出了这一承诺，但目前既没有强烈存在救助药物。对于他们或其他公司来说，现在是行动的时候; 2025在产品开发时间尺度方面并不遥远，气候不等待。

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