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首页> 外文期刊>Drug Design, Development and Therapy >Film-Forming Sprays for Topical Drug Delivery
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Film-Forming Sprays for Topical Drug Delivery

机译：用于局部药物递送的成膜喷雾剂

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Film-forming sprays offer many advantages compared to conventional topical preparations because they can provide uniform drug distribution and dose, increased bioavailability, lower incidence of irritation, continuous drug release, and accelerated wound healing through moisture control. Film-forming sprays consist of polymers and excipients that improve the characteristics of preparations and enhance the stability of active substances. Each type of polymer and excipient will produce films with different features. Therefore, the various types of polymers and excipients and their evaluation standards need to be examined for the development of a more optimal form of film-forming spray. The selected literature included research on polymers as film-forming matrices and the application of these sprays for medical purposes or for potential medical use. This article discusses the types and concentrations of polymers and excipients, sprayer types, evaluations, and critical parameters in determining the sprayability and film characteristics. The review concludes that both natural and synthetic polymers that have in situ film or viscoelastic properties can be used to optimise topical drug delivery.
机译：与常规局部制剂相比，成膜喷雾提供了许多优点，因为它们可以提供均匀的药物分布和剂量，增加生物利用度，刺激性较低，连续药物释放和加速伤口愈合通过水分控制。成膜喷雾组成的聚合物和赋形剂，可改善制剂的特性并增强活性物质的稳定性。每种类型的聚合物和赋形剂都会产生具有不同特征的薄膜。因此，需要检查各种类型的聚合物和赋形剂及其评估标准，以便开发更优选的成膜喷雾。所选择的文献包括对聚合物作为成膜基质的研究以及这些喷雾用于医疗目的或潜在医疗用途的应用。本文讨论了聚合物和赋形剂，喷雾器类型，评估和临界参数的类型和浓度在确定喷雾性和膜特征时。审查的结论是，具有原位膜或粘弹性的天然和合成聚合物可用于优化局部药物递送。

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