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Drug Prescription in Older Swiss Men and Women Followed in Family Medicine

机译：瑞士男性和妇女的药物处方，遵循家庭医学

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BackgroundWe sought to estimate the prevalence of polypharmacy, the most prevalent drug classes involved, and the prevalence and type of potentially inappropriate prescribing among older male and female patients in family medicine.MethodsWe conducted a secondary analysis of baseline data from a pragmatic cluster-randomised trial on the efficacy of a screening and management tool for geriatric syndromes among older community-dwelling patients (aged?≥?75?years) included by 42 family physicians. Information on drug prescription and clinical diagnoses (International Classification of Primary Care—2nd Edition [ICPC-2] coded) were extracted manually from medical records. The prevalence of polypharmacy, defined as the use of at least five permanent oral or parenteral drugs, and of potentially inappropriate medications (PIMs), identified according to 2015 updated Beers criteria, were compared between men and women.ResultsWe included 429 patients (269 women and 160 men; mean age 82.9 and 81.8?years, respectively). Polypharmacy was found in 59.9% of them. Analgesics, antithrombotic agents and agents acting on the renin-angiotensin system were the most frequently prescribed drug categories. Three-quarters of patients (76.7%) were prescribed at least one PIM according to Beers criteria, without difference by sex/gender ( p =?0.760). The most frequent PIMs were proton-pump inhibitors used for??8?weeks, diuretics, benzodiazepines, aspirin for primary prevention, and chronic use of non-steroidal anti-inflammatory drugs. Prescription patterns markedly differed by sex/gender, but the number and patterns of inappropriate prescriptions were comparable overall.InterpretationBoth polypharmacy and PIMs were very common in older patients followed regularly in family medicine in Switzerland. Interestingly, most PIMs involved only a limited number of medication classes.
机译：背景广告估计了多酚疾病的普遍性，涉及的最普遍的药物课程，以及家庭医学中老男性和女性患者的潜在不恰当处方的普遍性和类型。方法从务实的簇随机试验中对基线数据进行了二次分析在42家家庭医生中，较旧的社区住宅患者筛查和管理工具对老年社区综合征的疗效（老年人？≥？75岁）。有关药物处方和临床诊断的信息（初级护理 - 第二版[ICPC-2]编码的国际分类）从医疗记录中手动提取。根据2015年更新的BEERS标准确定了根据2015年更新的BEERS标准的使用至少五种常牙口服或肠胃外药物，以及潜在的药物（PIMS）的患病率，以及潜在的药物（PIMS）。培养人和女性。培养429名患者（269名妇女）和160名男子;平均年龄为82.9和81.8？多年）。 PolyPharmacy在其中的59.9％中被发现。作用于肾素 - 血管紧张素系统的镇痛药，抗血栓形成剂和药剂是最常见的药物类别。根据BEERS标准，在至少一个PIM规定了四分之三的患者（76.7％），无需按性别/性别（P = 0.760）。最常见的PIM是用于α> 8？8？周，利尿剂，苯二氮卓类药物的质子泵抑制剂，用于初级预防的阿司匹林，慢性使用非甾体抗炎药。性别/性别的处方模式显着不同，但不适当处方的数量和模式总体上是可比的。在瑞士的家庭医学中定期患者中经常在家庭医学中进行了相当的优势。有趣的是，大多数PIM涉及有限数量的药物课程。

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