...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>JBMR plus. >Calcium Supplement Use Is Associated With Less Bone Mineral Density Loss, But Does Not Lessen the Risk of Bone Fracture Across the Menopause Transition: Data From the Study of Women's Health Across the Nation
【24h】

Calcium Supplement Use Is Associated With Less Bone Mineral Density Loss, But Does Not Lessen the Risk of Bone Fracture Across the Menopause Transition: Data From the Study of Women's Health Across the Nation

机译：钙补充剂用途与较少的骨矿物密度损失有关，但不会减少全年期过渡过期骨折的风险：来自妇女在全国范围内的健康研究的数据

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Diet is a modifiable factor that is related to bone mass and risk for fractures; however, the use of calcium supplements for bone health is controversial, with little scientific agreement. The purpose of this analysis was to estimate the change in lumbar spine and femoral neck BMD and the risk of bone fracture by the use of calcium supplements among the Study of Women's Health Across the Nation (SWAN) participants. SWAN is a multicenter, multiethnic, community‐based longitudinal cohort designed to examine the health of women across the menopause transition ( n = 1490; aged 42 to 52?years at baseline in 1996 to 1997 and followed annually until 2006 to 2008). A mixed‐effect model for repeated measures was used to estimate annualized BMD change across time between supplement users and nonusers, unadjusted or fully adjusted (age, race, height, weight, menopausal status [pre‐, early peri‐, late peri‐, and postmenopausal], DXA scanner mode, alcohol intake, vitamin D supplement use, smoking, and physical activity) and a log‐linear model with repeated measures was used to estimate the relative risk of fracture by calcium supplement use. All models were also stratified by baseline menopausal status. In fully adjusted models, calcium supplement use was associated with less annualized loss of femoral neck BMD (?0.0032 versus ?0.0040?g/cm 2 /year; p ?.001) and lumbar spine BMD (?0.0046 versus ?0.0053?g/cm 2 /year, p = 0.021) in the complete cohort. However, this protective association of calcium supplement use with BMD loss was significant only among premenopausal women (femoral neck: ?0.0032 versus ?0.0042?g/cm 2 /year; p = 0.002; lumbar spine: ?0.0038 versus ?0.0050?g/cm 2 /year, p = 0.001); no significant differences in BMD were observed among women who were early perimenopausal by calcium supplement use at baseline. No significant differences in the relative risk of fracture were observed, regardless of baseline menopausal status. The use of calcium supplements was associated with less BMD loss over more than a decade, but was not related to the risk of incident bone fracture across the menopause transition. ? 2019 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.
机译：饮食是一种可修饰的因素，与骨骼质量有关和骨折风险;然而，使用钙补充剂对骨骼健康的争议是有争议的，具有很少的科学协议。该分析的目的是估算腰椎和股骨颈BMD的变化，通过在全国妇女健康研究中使用钙补充剂来抑制骨折的风险。天鹅是一个多中心，多民族，基于社区的纵向群体，旨在检查妇女的健康，整个更年期过渡（n = 1490; 1996年到1997年的基线时期为42至52岁，并在2006年至2008年之前随后随时随地进行。用于重复措施的混合效应模型用于估计补充用户和非用户之间的时间，不调整或完全调整（年龄，种族，身高，体重，更年期[预先，围灰，晚期，晚期，晚期）之间的年度BMD变化和后药物]，DXA扫描仪模式，酒精摄入，维生素D补充使用，吸烟和身体活动）和具有重复措施的对数线性模型用于通过钙补充使用来估计骨折的相对风险。所有模型也被基线更年期状态分层。在完全调整的模型中，钙补充剂使用与股骨颈部BMD的年度损失较少（0.0032对0.0040？G / cm 2 /年; P <β.001）和腰椎BMD（0.0046对0.0053？0.0053？ / cm 2 /年，p = 0.021）在完整的队列中。然而，这种保护性与BMD损失的钙补充剂损失只在前肢女性（股骨颈：0.0032对0.0042Ω·克/厘米/年; P = 0.002;腰椎：0.0038与λ0.0050？ cm 2 /年，p = 0.001）;通过在基线上使用钙补充剂使用早期外星缺血的女性未观察到BMD的显着差异。无论基线更年期状态如何，都没有观察到骨折的相对风险的显着差异。钙补充剂的使用与超过十年的BMD损失较少，但与在更年期过渡的事故骨折的风险无关。 ？ 2019年的作者。 JBMR Plus由Wiley Hearyicals，Inc。代表美国骨骼和矿物学研究。

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号