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首页> 外文期刊>Journal of Behavioral and Brain Science >Central Glutamatergic-Purinergic System Importance in Brain/Neural Plasticity
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Central Glutamatergic-Purinergic System Importance in Brain/Neural Plasticity

机译：中央谷氨酰胺 - 嘌呤能系统在脑/神经可塑性中重要性

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The proteolysis of the extracellular matrix plays a key role in the synaptic neuroplasticity of the central nervous system (CNS), which results in learning and memory. Proteases from the serine family and metalloproteinases of the extracellular matrix are localized within the synapses and are released into the extracellular space in proportion to the degree of neuronal excitation. These enzymes cause changes in the morphology, shape and size, and the overall number of synapses and synthesize new synaptic connections. The proteinase also changes the function of receptors, and consequently, the secretion of neurotransmitter/neuromodulator from the presynaptic glutamatergic and/or purinergic elements are either strengthened or weakened. Neuroglia involved in homeostasis, melanin synthesis and defense of the brain contain different combinations of purinergic receptors, which contributes to many neurotransmitters. This review summarizes a concept of brain plasticity, the role of ATP and P2 receptors interaction with glutamatergic system during plasticity of the brain in the one hand and after physical exercise in the other, which may be triggering phenomena facilitative synaptic plasticity as well as potentiates an personal efficiency to react to biobehavioral adaptation and disorders.
机译：细胞外基质的蛋白水解在中枢神经系统（CNS）的突触神经塑性中起关键作用，这导致学习和记忆。来自细胞外基质的丝氨酸家族和金属蛋白酶的蛋白酶在突触内局部化，与神经元激发程度成比例地释放到细胞外空间中。这些酶导致形态，形状和尺寸的变化，以及突触的整体数量和合成新的突触连接。蛋白酶还改变受体的功能，因此，来自突触前谷氨酸和/或嘌呤能元素的神经递质/神经调节剂的分泌是强化或削弱的。涉及稳态的神经节，黑色素合成和脑防御含有不同的嘌呤能受体组合，这有助于许多神经递质。本综述总结了脑可塑性的概念，ATP和P2受体在脑中的一种手中和在另一方面的脑部的可塑性期间与谷氨酸胶系统相互作用的概念，其它可能是触发现象促进突触可塑性以及增强剂个人效率与生物教生物适应和障碍作出反应。

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