A Mass Spectrometric Study of Kratom Compounds by Direct Infusion Electrospray Ionization Triple Quadrupole Mass Spectrometry

Hanzhuo Fu

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A Mass Spectrometric Study of Kratom Compounds by Direct Infusion Electrospray Ionization Triple Quadrupole Mass Spectrometry

机译：直接输注电喷雾电离三重四极孔质谱法的丙酸化合物的质谱研究

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Mitragynine (MG) and its major metabolites 7-hydroxymitragynine (7-OH-MG) are two of the major components of the plant extract Kratom, which is a tree planted in Southeast Asia. Kratom has long been used by opioid-dependent individuals as an alternative to their unavailable opioid of choice and chronic pain medication, as a stealth-to-urine drug screening opiate substitute while in opioid recovery treatment and recreationally, alone or as a booster. In this study, a direct infusion method was utilized and electrospray ionization triple quadrupole mass spectrometer was used as the detector for data acquisition. Pharmacokinetic study was conducted to investigate the effect of mitragynine and 7-hydroxymitragynine and major fragments of both compounds were proposed.

机译：米硝基胺（Mg）及其主要代谢物7-羟基吡咯（7-OH-Mg）是植物提取物Kratom的两种主要成分，这是在东南亚种植的树。 Kratom已经被阿片类药物依赖的个体使用，作为他们无法使用的选择和慢性疼痛药物的不可用的阿片类药物，作为一种隐形对尿液药物筛选的鸦片替代品，而在阿片类药物恢复治疗中，单独或作为助推器娱乐。在该研究中，利用直接输注方法，使用电喷雾电离三倍四极杆质谱仪作为数据采集的检测器。进行了药代动力学研究以研究咪丙氨酸和7-羟基吡咯的作用，提出了两种化合物的主要碎片。

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《Detection》 |2016年第3期|共7页
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Hanzhuo Fu;
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A Mass Spectrometric Study of Kratom Compounds by Direct Infusion Electrospray Ionization Triple Quadrupole Mass Spectrometry

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