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首页> 外文期刊>Journal of Biomedical Engineering and Technology >3D Modeling and Simulation of Airflow and Aerosol Deposition of 5 Years Child
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3D Modeling and Simulation of Airflow and Aerosol Deposition of 5 Years Child

机译：5年儿童气流和气溶胶沉积的3D建模与仿真

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Children have special requirements in pulmonary drug delivery, as their lungs evolve continuously until they become adult. To deliver the drug to a specific area in the appropriate quantity, we need to study the deposition of particles. In our study we modelled and simulated airflow on a 5-year-old child using a CAD software to understand aerosol deposition. To design and simply the model of a child URT (Upper Respiratory Tract) on a CAD (Computer Aided Design) Software. Child specific model consist of mouth, trachea, and bronchi (leftandright) with 11, 9, and 6.2 years old, respectively, was adopted. Using SolidWorks the URT model was sketched and extruded. All the simulation works were performed using software ANSYS CFX. An aerosol deposition converges at a steady-state condition for 500 iterations. A decrease in discharge was recorded as deposition transits from contraction prior to trachea at a velocity of 15 mm/s and a count of approximation of 28,000 with a time-lapse of 5 seconds. Therefore, the pressure and velocity of the particulate increases due to the contraction. Formulation particulate maximum velocity was recorded at 0.26 mm/s. Our findings suggest that a five-year-old URT model of a child has more aerosol depositions in comparison to adults and aerosol size range will evolve with age. In addition, deposition increase directly proportional to flow rate and with particle diameter.
机译：儿童在肺药递送方面具有特殊要求，因为它们的肺部连续发展直至它们成为成人。为了以适当的数量将药物送到特定区域，我们需要研究粒子的沉积。在我们的研究中，我们使用CAD软件来了解5岁儿童的模拟和模拟气流，以了解气溶胶沉积。设计，简单地设计了CAD（计算机辅助设计）软件上的儿童URT（上呼吸道）的模型。儿童特异性模型包括口，气管和支气管（Heltandandright），分别采用11,9和6.2岁。使用SolidWorks，速写和挤压URT模型。所有仿真工作都是使用软件ANSYS CFX进行的。气溶胶沉积在500次迭代处的稳态条件下会聚。记录放电的降低作为沉积转运从气管之前的收缩速度，以15mm / s的速度，并且时间流逝为5秒钟的近似的近似。因此，由于收缩，颗粒的压力和速度增加。配方颗粒最大速度记录在0.26mm / s。我们的研究结果表明，与成人和气溶胶尺寸范围相比，一名五岁的孩子的URT模型具有更多的气溶胶沉积，而气溶胶尺寸范围将随着年龄的增长而发展。另外，沉积增加与流速和粒径成正比。

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