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首页> 外文期刊>Journal of Addiction >Estimating Mental Health Conditions of Patients with Opioid Use Disorder
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Estimating Mental Health Conditions of Patients with Opioid Use Disorder

机译：估算阿片类药物使用障碍患者的心理健康状况

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Objectives. Noninvasive estimation of cortical activity aberrance may be a challenge but gives valuable clues of mental health in patients. The goal of the present study was to characterize specificity of electroencephalogram (EEG) electrodes used to assess spectral powers associated with mental health conditions of patients with opioid use disorder. Methods. This retrospective study included 16 patients who had been diagnosed with opioid use disorder in comparison with 16 sex- and age-matched healthy controls. EEG electrodes were placed in the frontal (FP1, FP2, F3, F4, F7, F8, and Fz), central (C3, C4, and Cz), temporal (T3, T4, T5, and T6), parietal (P3, P4, and Pz), and occipital scalp (O1 and O2). Spectral powers of δ, θ, α, β, and γ oscillations were determined, and their distribution was topographically mapped with those electrodes on the scalp. Results. Compared to healthy controls, the spectral powers at low frequencies (8?Hz; δ and θ) were increased in most electrodes across the scalp, while powers at the high frequencies (12?Hz; β and γ) were selectively increased only at electrodes located in the frontal and central scalp. Among 19 electrodes, F3, F4, Fz, and Cz were highly specific in detecting increases in δ, θ, β, and γ powers of patients with opioid use disorders. Conclusion. Results of the present study demonstrate that spectral powers are topographically distributed across the scalp, which can be quantitatively characterized. Electrodes located at F3, F4, Fz, and Cz could be specifically utilized to assess mental health in patients with opioid use disorders. Mechanisms responsible for neuroplasticity involving cortical pyramidal neurons and μ-opioid receptor regulations are discussed within the context of changes in EEG microstates.
机译：目标。皮质活动的非侵入性估计可能是挑战，但患者患有患者的心理健康有价值的线索。本研究的目的是表征用于评估与阿片类药物使用障碍患者的心理健康状况相关的光谱势的脑电图（EEG）电极的特异性。方法。该回顾性研究包括16名患者，该患者被诊断出患有阿片类药物使用障碍，与16名性别和年龄匹配的健康对照组相比。将EEG电极置于额头（FP1，FP2，F3，F4，F7，F8和FZ），中央（C3，C4和CZ），时间（T3，T4，T5和T6），间（P3， P4和PZ）和枕骨头皮（O1和O2）。确定Δ，θ，α，β和γ振荡的光谱功率，并且它们的分布在头皮上的那些电极进行地拓扑映射。结果。与健康对照相比，在头皮上的大多数电极中，低频（<8·Hz;δ和θ）的光谱功率增加，而在高频（>12≤Hz;β和γ）中的功率仅升高在位于额头和中央头皮的电极。在19个电极中，F3，F4，FZ和CZ在检测Δ，θ，β和γ功率的增加时具有高度特异性的阿片类药物使用障碍的患者的增加。结论。本研究结果表明，光谱功率在拓扑上分布在头皮上，其可以定量表征。位于F3，F4，FZ和CZ的电极可以具体用于评估阿片类药物使用障碍患者的心理健康。负责涉及皮质锥形神经元和μ-ApiOID受体法规的神经塑性的机制在EEG MicroState的变化的范围内讨论。

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