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首页> 外文期刊>Journal of Clinical Medicine >Metabolomic Analysis Reveals Distinct Profiles in the Plasma and Urine Associated with IgE Reactions in Childhood Asthma
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Metabolomic Analysis Reveals Distinct Profiles in the Plasma and Urine Associated with IgE Reactions in Childhood Asthma

机译：代谢物分析揭示了与儿童哮喘中的IgE反应相关的血浆和尿液中明显的曲线

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Several metabolomics studies have identified altered metabolic pathways that are related to asthma. However, an integrative analysis of the metabolic responses across blood and urine for a comprehensive framework of asthma in early childhood remains lacking. Fifty-four age-matched children with asthma (n = 28) and healthy controls (n = 26) were enrolled. Metabolome analysis of the plasma and urine samples was performed using 1 H-nuclear magnetic resonance (NMR) spectroscopy coupled with partial least-squares discriminant analysis (PLS-DA). Integrated analysis of blood and urine metabolic profiling related to IgE reactions for childhood asthma was investigated. A significantly higher plasma histidine level was found, in parallel with lower urinary 1-methylnicotinamide and trimethylamine N-oxide (TMAO) levels, in children with asthma compared to healthy controls. Compared to children without allergic sensitization, 11 (92%) plasma metabolites and 8 (80%) urinary metabolites were found to be significantly different in children with IgE and food sensitization respectively. There were significant correlations between the plasma 3-hydroxybutyric acid and excreted volumes of the hydroxy acids, which were strongly correlated to plasma leucine and valine levels. Urine N-phenylacetylglycine, a microbial-host co-metabolite, was strongly correlated with total serum and food allergen-specific IgE levels. Plasma pyruvate and urine valine, leucine, and isoleucine degradation metabolisms were significantly associated with allergic sensitization for childhood asthma. In conclusion, blood and urine metabolome reflect different metabolic pathways in allergic reactions. Plasma pyruvate metabolism to acetic acid appears to be associated with serum IgE production, whereas urine branched-chain amino acid metabolism primarily reflects food allergic reactions against allergies.
机译：几项代谢组研究已经确定了与哮喘有关的改变的代谢途径。然而，对童年早期患有综合哮喘综合术框架的血液和尿液中的代谢反应的综合分析仍然缺乏。注册了54名患有哮喘（n = 28）和健康对照的儿童（n = 26）。使用1 H核磁共振（NMR）光谱与部分最小二乘判别分析（PLS-DA）耦合的血浆和尿样的代谢物分析。研究了对儿童哮喘的IgE反应相关的血液和尿液代谢分析的综合分析。与健康对照相比，在哮喘的儿童中，发现了与低尿1-甲基喹喔啉和三甲胺N-氧化物（TMAO）水平平行的血浆组氨酸水平显着更高。与没有过敏性敏感的儿童相比，11（92％）血浆代谢物和8（80％）尿代谢物分别在IgE和食物致敏的儿童中发现显着不同。血浆3-羟基丁酸和排泄体积的羟基酸之间存在显着的相关性，其与血浆亮氨酸和缬氨酸水平密切相关。尿N-苯基乙酰甘氨酸，微生物宿主共代谢物与总血清和食物过敏原特异性IgE水平强烈相关。血浆丙酮酸和尿缬氨酸，亮氨酸和异亮氨酸降解代谢与儿童哮喘的过敏性敏化显着相关。总之，血液和尿液代谢物反映了过敏反应中的不同代谢途径。血浆丙酮酸代谢对乙酸似乎与血清IgE产生相关，而尿枝链氨基酸代谢主要反映了对过敏的食物过敏反应。

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