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首页> 外文期刊>Journal of Clinical Medicine >The Burden of Associated Comorbidities in Patients with Obstructive Sleep Apnea—Regional Differences in Two Central–Eastern European Sleep Centers
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The Burden of Associated Comorbidities in Patients with Obstructive Sleep Apnea—Regional Differences in Two Central–Eastern European Sleep Centers

机译：患者患者患者的患者联系休眠呼吸暂停症 - 欧洲睡眠中心差异的负担

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Background: Obstructive sleep apnea (OSA) is usually associated with cardiovascular and cerebrovascular disease, metabolic syndrome and depression. Data on relevant OSA-associated comorbidities in Central–European populations are scarce. The aim of this study was to compare the prevalence of comorbidities in two OSA cohorts from Hungary and Romania. Methods: Data from 588 (282 from Hungary, 306 from Romania) untreated patients with OSA were retrospectively analyzed. The prevalence rates of hypertension, diabetes, dyslipidemia, allergic rhinitis, asthma, chronic obstructive pulmonary disease (COPD), osteoporosis, cerebrovascular and cardiovascular disease, arrhythmia and depression were compared between the two populations following adjustment for demographics, body mass index, smoking history, comorbidities and sleep parameters. Results: The prevalence rates of hypertension, arrhythmia, cerebrovascular and cardiovascular disease, diabetes and COPD in the whole study population were directly related to the severity of OSA. We found an inverse correlation between the prevalence of osteoporosis and OSA severity (all p 0.05). Following adjustment, the prevalence of dyslipidemia was higher in the Hungarian cohort, whilst the prevalence of asthma, cardiovascular and cerebrovascular diseases was higher in the Romanian cohort (all p 0.05). Conclusions: There was no difference in the prevalence rate of most comorbidities in patients with OSA from the two cohorts, except for dyslipidemia, asthma, cardiovascular and cerebrovascular disease.
机译：背景：阻塞性睡眠呼吸暂停（OSA）通常与心血管和脑血管疾病，代谢综合征和抑郁有关。中欧群体中相关OSA相关合并症的数据稀缺。本研究的目的是比较来自匈牙利和罗马尼亚的两个OSA队列中的合并症的患病率。方法：回顾性分析588（匈牙利，罗马尼亚306人）的数据，重新分析了OSA的未经处理的OSA患者。在调整人口统计数据，体重指数，吸烟历史后，比较了高血压，糖尿病，血脂腺炎，过敏性鼻炎，哮喘，慢性阻塞性肺病，心律失常和抑郁症，心律失常和抑郁症，心律失常和抑郁症，合并症和睡眠参数。结果：整个研究人群中高血压，心律失常，脑血管和心血管疾病，糖尿病和COPD的患病率与OSA的严重程度直接相关。我们发现骨质疏松症和OSA严重程度之间的逆相关性（所有P <0.05）。调整后，匈牙利队列的血脂血症患病率较高，而罗马尼亚队患者的哮喘，心血管和脑血管病的患病率较高（所有P <0.05）。结论：OSA患者从两群患者的患者患病率没有差异，除了血脂血症，哮喘，心血管和脑血管病。

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