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首页> 外文期刊>Journal of Clinical Medicine >Exercise Training Protects against Atorvastatin-Induced Skeletal Muscle Dysfunction and Mitochondrial Dysfunction in the Skeletal Muscle of Rats
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Exercise Training Protects against Atorvastatin-Induced Skeletal Muscle Dysfunction and Mitochondrial Dysfunction in the Skeletal Muscle of Rats

机译：运动训练可以防止阿托伐他汀诱导的骨骼肌功能障碍和大鼠骨骼肌中的线粒体功能障碍

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Statins are used to prevent and treat atherosclerotic cardiovascular disease, but they also induce myopathy and mitochondrial dysfunction. Here, we investigated whether exercise training prevents glucose intolerance, muscle impairment, and mitochondrial dysfunction in the skeletal muscles of Wistar rats treated with atorvastatin (5 mg kg ?1 day ?1 ) for 12 weeks. The rats were assigned to the following three groups: the control (CON), atorvastatin-treated (ATO), and ATO plus aerobic exercise training groups (ATO+EXE). The ATO+EXE group exhibited higher glucose tolerance and forelimb strength and lower creatine kinase levels than the other groups. Mitochondrial respiratory and Ca 2+ retention capacity was significantly lower in the ATO group than in the other groups, but exercise training protected against atorvastatin-induced impairment in both the soleus and white gastrocnemius muscles. The mitochondrial H 2 O 2 emission rate was relatively higher in the ATO group and lower in the ATO+EXE group, in both the soleus and white gastrocnemius muscles, than in the CON group. In the soleus muscle, the Bcl-2, SOD1, SOD2, Akt, and AMPK phosphorylation levels were significantly higher in the ATO+EXE group than in the ATO group. In the white gastrocnemius muscle, the SOD2, Akt, and AMPK phosphorylation levels were significantly higher in the ATO+EXE group than in the ATO group. Therefore, exercise training might regulate atorvastatin-induced muscle damage, muscle fatigue, and mitochondrial dysfunction in the skeletal muscles.
机译：他汀类药物用于预防和治疗动脉粥样硬化心血管疾病，但它们也诱导肌病和线粒体功能障碍。在这里，我们调查了运动训练是否可防止葡萄糖不耐受，肌肉损伤和线粒体损伤和线粒体功能障碍在用阿托伐他汀（5mg kg？1天α1）治疗的Wistar大鼠的骨骼肌中12周。将大鼠分配到以下三组：对照（CON），阿托伐他汀治疗（ATO）和ATO加有氧运动训练组（ATO + EXE）。 ATO + EXE组表现出更高的葡萄糖耐量和前肢强度，而不是其他组的肌酸激酶水平。 ATO组的线粒体呼吸和Ca 2+保留能力明显低于其他组，但在肌肉和白色腓肠肌肌肉中保护患者免受阿托伐他汀诱导的损伤的运动培训。在ATO组中，线粒体H 2 O 2发射率相对较高，在ATO + EXE组中较低，肌肉和白色腓肠肌肌肉比在孔组中。在ATO + EXE组中，在SOLEUS肌肉中，BCL-2，SOD1，SOD 2，AKT和AMPK磷酸化水平显着高于ATO组。在白色腓肠肌肌肉中，在ATO + EXE组中，SOD2，AKT和AMPK磷酸化水平明显高于ATO组。因此，运动培训可能会调节阿托伐他汀诱导的肌肉损伤，肌肉疲劳和线粒体功能障碍在骨骼肌中。

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