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Sleep Impairment and Psychological Distress among Patients with Inflammatory Bowel Disease—beyond the Obvious

机译：炎症性肠病患者的睡眠障碍和心理窘迫 - 超出明显

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Background: A healthy sleep–wake cycle is fundamental for regulating immune function. Sleepiness and fatigue are often manifestations of chronic inflammatory disorders, such as inflammatory bowel disease (IBD), potentially influencing the course of the disease. Our aim was to characterize sleep impairment in patients with IBD and to identify potential associated factors. Methods: We conducted a single-center prospective case control study including IBD patients and healthy controls. We evaluated clinical and biochemical parameters, sleep impairment through Pittsburgh Sleep Quality Index (PSQI) and anxiety and depression through Hospital Anxiety and Depression Scale (HADS) questionnaires. Results: In total, 110 patients with IBD and 66 healthy controls were included. Patients with IBD had a significantly altered sleep quality compared to the control group ( p 0.001), with sleep impairment also occurring for patients in remission (median PSQI = 7), but without significant differences between ulcerative colitis and Crohn’s disease. However, PSQI was correlated with disease activity scores only for ulcerative colitis and not for Crohn’s disease. Among patients with increased PSQI, only 30.19% used sleep medication. Sleep impairment was significantly correlated with altered psychological status ( p 0.01) and the presence of extraintestinal manifestations ( p = 0.0172). Conclusions: Sleep impairment is frequent among patients with IBD, is associated with psychological distress and several disease-related parameters and should be routinely evaluated, at least in several IBD patient subgroups, to improve disease management.
机译：背景：健康的睡眠唤醒循环是调节免疫功能的基础。嗜睡和疲劳往往是慢性炎症疾病的表现，例如炎症性肠病（IBD），可能影响疾病的过程。我们的目标是在IBD患者中表征睡眠障碍，并识别潜在的相关因素。方法：我们进行了单中心前瞻性案例控制研究，包​​括IBD患者和健康对照。我们评估了临床和生化参数，通过匹兹堡睡眠质量指数（PSQI）和焦虑和抑郁通过医院焦虑和抑郁规模（曾）问卷调查问卷的临床和生化参数。结果：总共110例IBD和66名健康对照。与对照组相比，IBD患者具有显着改变的睡眠质量（P <0.001），睡眠损伤也发生了睡眠损伤（中位数Psqi = 7），但没有溃疡性结肠炎和克罗恩病之间的显着差异。然而，PSQI仅与疾病活动分数相关，仅针对溃疡性结肠炎，而不是克罗恩病。在PSQI增加的患者中，只有30.19％的睡眠药物。睡眠障碍与改变的心理状态（P <0.01）和外来表现出存在显着相关（P = 0.0172）。结论：IBD患者频繁出现睡眠障碍，与心理困扰和几个疾病相关参数有关，应至少在几个IBD患者亚组中进行常规评估，以改善疾病管理。

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