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首页> 外文期刊>Journal of Clinical Medicine >Scores of Health-Related Quality of Life Questionnaire Worsen Consistently in Patients of COPD: Estimating Disease Progression over 30 Years by SReFT with Individual Data Collected in SUMMIT Trial
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Scores of Health-Related Quality of Life Questionnaire Worsen Consistently in Patients of COPD: Estimating Disease Progression over 30 Years by SReFT with Individual Data Collected in SUMMIT Trial

机译：健康相关的生活质量调查问卷始终如一地对COPD患者持续恶化：估计30年以上的疾病进展，通过峰会试验中收集的个别数据进行了30年

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The aim of this study was to elucidate the lifelong disease progression of chronic obstructive pulmonary disease (COPD) with biomarker changes and identify their influencing factors, by utilizing a new analysis method, Statistical Restoration of Fragmented Time-course (SReFT). Individual patient data ( n = 1025) participating in the Study to Understand Mortality and MorbidITy (SUMMIT, NCT01313676), which was collected within the observational period of 4 years, were analyzed. The SReFT analysis suggested that scores of St. George’s Respiratory Questionnaire and COPD assessment test, representative scores of the health-related quality of life (HRQOL) questionnaire, increased consistently for 30 years of disease progression, which was not detected by conventional analysis with a linear mixed effect model. It was estimated by the SReFT analysis that normalized forced expiratory volume in one second for age, sex, and body size (%FEV1) reduced for the initial 10 years from the onset of the disease but thereafter remained constant. The analysis of HRQOL scores and lung functions suggested that smoking cessation slowed COPD progression by approximately half and that exacerbation accelerated it considerably. In conclusion, this retrospective study utilizing SReFT elucidated the progression of COPD over 30 years and associated quantitative changes in the HRQOL scores and lung functions.
机译：本研究的目的是通过利用新的分析方法，统计恢复分散的时间课程（SREFT），阐明慢性阻塞性肺病（COPD）的终身疾病进展，并确定其影响因素。分析了参与研究以了解在观察期内的死亡率和发病率（峰会，NCT01313676）的个人患者数据（n = 1025）分析​​了在4岁的观察期内收集的。 SREFT分析表明，ST.乔治的呼吸问卷和COPD评估试验，有关的健康状生活质量（HRQOL）调查问卷的代表性评价持续增加了30年的疾病进展，该进展始终如一，常规分析未检测到线性混合效果模型。据估计，SREF分析估计，归一化强制呼气量在一秒钟内，性别和体积（％FEV1）从疾病的发作后减少了最初的10年，但此后保持恒定。 HRQOL分数和肺功能分析表明，吸烟停止将COPD进展放缓大约一半，并且加剧加剧了很大程度上。总之，利用SREFT的回顾性研究阐明了30多年的COPD的进展，并且HRQOL分数和肺功能相关的定量变化。

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