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首页> 外文期刊>Journal of Clinical Medicine >Application of Anti-Inflammatory Agents in Prostate Cancer
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Application of Anti-Inflammatory Agents in Prostate Cancer

机译：抗炎药在前列腺癌中的应用

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Chronic inflammation is a major cause of human cancers. The environmental factors, such as microbiome, dietary components, and obesity, provoke chronic inflammation in the prostate, which promotes cancer development and progression. Crosstalk between immune cells and cancer cells enhances the secretion of intercellular signaling molecules, such as cytokines and chemokines, thereby orchestrating the generation of inflammatory microenvironment. Tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs) play pivotal roles in inflammation-associated cancer by inhibiting effective anti-tumor immunity. Anti-inflammatory agents, such as aspirin, metformin, and statins, have potential application in chemoprevention of prostate cancer. Furthermore, pro-inflammatory immunity-targeted therapies may provide novel strategies to treat patients with cancer. Thus, anti-inflammatory agents are expected to suppress the “vicious cycle” created by immune and cancer cells and inhibit cancer progression. This review has explored the immune cells that facilitate prostate cancer development and progression, with particular focus on the application of anti-inflammatory agents for both chemoprevention and therapeutic approach in prostate cancer.
机译：慢性炎症是人类癌症的主要原因。环境因素，如微生物组，膳食成分和肥胖症，引发前列腺慢性炎症，促进癌症发展和进展。免疫细胞和癌细胞之间的串扰增强了细胞间信号分子的分泌，例如细胞因子和趋化因子，从而促进炎性微环境的产生。通过抑制有效的抗肿瘤免疫，肿瘤相关的巨噬细胞（TAMS）和髓样衍生的抑制细胞（MDSCS）在炎症相关癌症中起枢转作用。抗炎剂，如阿司匹林，二甲双胍和他汀类药物，对前列腺癌的化学预防有潜力。此外，促炎症免疫靶向疗法可提供新的治疗癌症患者的新策略。因此，预期抗炎剂会抑制免疫和癌细胞产生的“恶性循环”并抑制癌症进展。本综述已探讨了促进前列腺癌发展和进展的免疫细胞，特别关注抗炎剂在前列腺癌中的化学预防和治疗方法的应用。

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