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首页> 外文期刊>Journal of Clinical Medicine >CD200 and CD200R Expression on Peripheral Blood Lymphocytes and Serum CD200 Concentration as a New Marker of Endometriosis
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CD200 and CD200R Expression on Peripheral Blood Lymphocytes and Serum CD200 Concentration as a New Marker of Endometriosis

机译：CD200和CD200R表达外周血淋巴细胞和血清CD200浓度作为子宫内膜异位症的新标志物

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The causes of endometriosis (EMS) remain unknown; however, a number of immunological abnormalities contribute to the pathogenesis of the disease. The cluster of differentiation-200 (CD200) and its receptor (CD200R) maintain peripheral self-tolerance by negatively regulating immune responses. In this comparative cross-sectional study, we investigated the expression of CD200 and CD200R on T and B lymphocytes and the serum level of soluble CD200 (sCD200) using flow cytometry and ELISA, respectively. Peripheral blood samples were collected from 54 female patients and 20 healthy, age-matched controls. Results were tested for correlation with disease severity and selected clinical parameters. We demonstrated that the differences in sCD200 levels ( p = 0.001), the frequencies of CD200-positive T and B lymphocytes ( p 0.001 and p = 0.004, respectively), and the frequencies of CD200R-positive T and B lymphocytes ( p 0.001 for all comparisons) in the study group correlated positively with disease severity. Receiver operating characteristic (ROC) analysis indicated that aberrant expression of CD200/CD200R might serve as a marker to distinguish between EMS cases. Finally, negative co-stimulatory factors may contribute to the induction and persistence of inflammation associated with EMS. It seems that it is essential to determine whether alteration in the CD200/CD200R pathway can be therapeutically targeted in EMS.
机译：子宫内膜异位症（EMS）的原因仍然未知;然而，许多免疫学异常有助于疾病的发病机制。分化-200（CD200）及其受体（CD200R）的簇通过对抗免疫应答来保持外周自耐受。在该比较的横截面研究中，我们研究了流式细胞术和ELISA的CD200和CD200R对T和B淋巴细胞的表达和可溶性CD200（SCD200）的血清水平。从54名女性患者和20名健康，年龄匹配的对照中收集外周血样品。测试结果与疾病严重程度和选择的临床参数相关。我们证明SCD200水平的差异（p = 0.001），CD200阳性T和B淋巴细胞的频率（P <0.001和P = 0.004），以及CD200R阳性T和B淋巴细胞的频率（P <在研究组中的所有比较为0.001，患疾病严重程度正相关。接收器操作特征（ROC）分析表明CD200 / CD200R的异常表达可以用作区分EMS案例的标记。最后，阴性共刺激因子可能有助于与EMS相关的炎症的诱导和持久性。似乎必须确定CD200 / CD200R途径是否可以在EMS治疗上靶向。

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