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首页> 外文期刊>Journal of Clinical Medicine >Characterization of Fetal Thyroid Levels at Delivery among Appalachian Infants
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Characterization of Fetal Thyroid Levels at Delivery among Appalachian Infants

机译：阿巴拉契亚婴幼儿递送胎儿甲状腺水平的特征

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Thyroid disorders are a frequently encountered issue during pregnancy and a cause of maternal and fetal morbidity. In regions like Appalachia that are particularly susceptible to health disparities, descriptive studies are needed to assist in identifying pathologic derangements. We sought to characterize fetal thyroid hormone levels at delivery and investigate whether or not maternal demographic characteristics affect the prevalence of neonatal thyroid disease. A cross-sectional analysis was conducted on 130 pregnant women recruited from the Tri-State region, incorporating areas of Kentucky, Ohio, and West Virginia. Total triiodothyronine (T3) ( p = 0.4799), free T3 ( p = 0.6323), T3 uptake ( p = 0.0926), total thyroxine (T4) ( p = 0.8316), free T4 ( p = 0.0566), and Thyroid stimulating hormone (TSH) ( p = 0.8745) levels were comparable between urban and rural newborns. We found no effect of hypertension status or nicotine levels on fetal umbilical cord thyroid hormone levels. Maternal diabetic status was associated with lower T4 ( p = 0.0099) and free T4 ( p = 0.0025) levels. Cotinine affected levels of T4 ( p = 0.0339). In regard to maternal Body Mass Index (BMI), there was an increase in total T3 as BMI increased ( p = 0.0367) and no significant difference in free T3, T3 uptake, T4, free T4, or TSH. There was a negative correlation between TSH and 1 min Apgar scores ( p = 0.0058). Lead and cadmium have been implicated to alter TSH levels, but no correlation was found in our study (r 2 = 0.0277). There were no differences in cord blood between urban (37.3 ± 10.3 fmol/ug DNA) and rural (70.5 ± 26.8 fmol/ug DNA) benzo(a)pyrene DNA adducts ( p = 0.174). Thyroid disorders present a unique opportunity for the prevention of perinatal morbidity and mortality, since maternal treatment, as well as maternal demographic characteristics, can have direct fetal effects.
机译：甲状腺疾病是怀孕期间经常遇到的问题，母亲和胎儿发病原因。在尤其容易受到健康差异的胃癌等地区中，需要描述性研究以协助识别病理紊乱。我们试图在交付时表征胎儿甲状腺激素水平，并调查孕产性人口统计特征是否影响新生儿甲状腺疾病的患病率。在从三国区域招募的130名孕妇中进行了横截面分析，纳入了肯塔基州，俄亥俄州和西弗吉尼亚州的地区。全三碘甲酚（T3）（P = 0.4799），自由T3（P = 0.6323），T3吸收（P = 0.0926），总甲状腺素（T4）（P = 0.8316），免费T4（P = 0.0566），以及甲状腺刺激激素（TSH）（P = 0.8745）水平与城乡新生儿之间相当。我们发现高血压状态或尼古丁水平对胎儿脐带甲状腺激素水平没有影响。母体糖尿病状态与较低的T4（p = 0.0099）和游离T4（p = 0.0025）水平相关。 Cotinine受影响的T4水平（p = 0.0339）。关于母体体重指数（BMI），总T3增加，因为BMI增加（p = 0.0367），并且游离T3，T3摄取，T4，免费T4或TSH没有显着差异。 TSH和1分钟的APGAR分数之间存在负相关（P = 0.0058）。铅和镉致力于改变TSH水平，但在我们的研究中没有发现相关性（R 2 = 0.0277）。城市（37.3±10.3型FMOL / UG DNA）和农村（70.5±26.8 fmol / ug DNA）苯并（a）芘DNA加合物（P = 0.174）之间没有差异。甲状腺疾病为预防围产期发病率和死亡率的独特机会，因为母体治疗，以及母体人口统计学，可具有直接的胎儿效应。

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