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首页> 外文期刊>Journal of Clinical Medicine >Decreased Cerebrospinal Fluid Orexin-A (Hypocretin-1) Concentrations in Patients after Generalized Convulsive Status Epilepticus
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Decreased Cerebrospinal Fluid Orexin-A (Hypocretin-1) Concentrations in Patients after Generalized Convulsive Status Epilepticus

机译：在广义惊厥状态癫痫患者患者中减少脑脊髓液-A（尿道素-1）浓度

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The effects of status epilepticus on the orexin/hypocretin system have yet to be investigated. The present study aimed to assay orexin-A/hypocretin-1 in the cerebrospinal fluid (CSF) of patients after generalized convulsive status epilepticus (GCSE). The study groups included 20 GCSE patients, 24 patients diagnosed with epilepsy but remaining in remission (ER), and 25 normal controls (CTR). Diagnostic lumbar puncture was performed in GCSE patients within 3–10 days of seizure cessation, as well as in the ER and to CTR subjects. Among all GCSE patients, the outcome was graded according to the modified Rankin Scale (mRS) at 1-month follow-up. Orexin-A levels were measured in unextracted CSF samples, using a commercial radioimmunoassay. There was a significant overall difference in median CSF orexin-A concentrations between GCSE, RE, and CTR patients ( p 0.001). The lowest concentrations were noted in the GCSE group compared to ER ( p 0.001) or CTR ( p 0.001). CSF orexin-A levels in GCSE patients inversely correlated with clinical outcome as assessed on the mRS at 1-month follow-up ( r = ?0.55; p = 0.1). In conclusion, CSF orexin-A levels may serve as a biomarker of increased turn-over of the peptide or post-SE neuronal damage, and implicates the orexin system in the pathogenesis of SE.
机译：状态癫痫患者对orexin / hubocretin系统的影响还尚未调查。本研究旨在在广泛的惊厥状态癫痫患者（GCSE）后患者脑脊液（CSF）中的颅内-a / undocretin-1。该研究组包括20名GCSE患者，24名患者被诊断患有癫痫患者，但留在缓解（ER）和25名正常对照（CTR）中。诊断腰椎穿刺在癫痫发作停止的3-10天内，以及ER和CTR受试者的3-10天内进行。在所有GCSE患者中，结果根据修改的Rankin规模（MRS）在1个月的随访中进行了分级。使用商业放射免疫测定，在未提出的CSF样品中测量orexin-a水平。中位数CSF orexin-A浓度在GCSE，RE和CTR患者之间存在显着的总体差异（P <0.001）。与ER（P <0.001）或CTR（P <0.001）相比，GCSE组中注意到最低浓度。 CSF Orexin-A中的GCSE患者的水平与临床结果与1个月后续的MRS评估的临床结果相关（R = 0.55; p = 0.1）。总之，CSF orexin-A水平可以用作肽或硒后神经元损伤的增加的生物标志物，并暗示奥克替斯系统在SE的发病机制中。

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