• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical Medicine >Bone Loss, Osteoporosis, and Fractures in Patients with Rheumatoid Arthritis: A Review
【24h】

Bone Loss, Osteoporosis, and Fractures in Patients with Rheumatoid Arthritis: A Review

机译：类风湿性关节炎患者骨质损失，骨质疏松症和骨折：综述

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Rheumatoid arthritis (RA) is often characterized by bone loss and fragility fractures and is a frequent comorbidity. Compared with a matched population, RA patients with fractures have more common risk factors of osteoporosis and fragility fractures but also risk factors resulting from the disease itself such as duration, intensity of the inflammation and disability, and cachexia. The inflammatory reaction in the synovium results in the production of numerous cytokines (interleukin-1, interleukin-6, tumor necrosis factor) that activate osteoclasts and mediate cartilage and bone destruction of the joints, but also have a systemic effect leading to generalized bone loss. Regular bone mineral density (BMD) measurement, fracture risk assessment using tools such as the FRAX algorithm, and vertebral fracture assessment (VFA) should be performed for early detection of osteoporosis and accurate treatment in RA patients.
机译：类风湿性关节炎（RA）通常是骨质损失和脆性骨折的特征，并且是常意的合并率。与匹配的人群相比，RA骨折的RA患者具有更高的骨质疏松症和脆性骨折的危险因素，而且患有疾病本身的危险因素，如炎症和残疾的持续时间，强度，和恶病症。 Synovium中的炎症反应导致产生众多细胞因子（白细胞介素-1，白细胞介素-6，肿瘤坏死因子），其激活破骨细胞和介导关节的软骨和骨破坏，但也具有导致广义骨质损失的全身效应。应进行常规骨矿物密度（BMD）测量，使用诸如Frax算法等工具和椎骨骨折评估（VFA）的骨折风险评估，以便早期检测RA患者的骨质疏松症和准确治疗。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号