• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical Medicine >Impaired Right and Left Ventricular Longitudinal Function in Patients with Fibrotic Interstitial Lung Diseases
【24h】

Impaired Right and Left Ventricular Longitudinal Function in Patients with Fibrotic Interstitial Lung Diseases

机译：纤维化间质性肺病患者的右心室纵向功能受损

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Left ventricular (LV) and right ventricular (RV) dysfunction is recognized in idiopathic pulmonary fibrosis (IPF). Little is known about cardiac involvement in non-idiopathic pulmonary fibrosis (no-IPF). This issue can be explored by advanced echocardiography. Methods: Thirty-three clinically stable and therapy-naive fibrotic IPF and 28 no-IPF patients, and 30 healthy controls were enrolled. Exclusion criteria were autoimmune systemic diseases, coronary disease, heart failure, primary cardiomyopathies, chronic obstructive lung diseases, pulmonary embolism, primary pulmonary hypertension. Lung damage was evaluated by diffusion capacity for carbon monoxide (DLCO sb ). All participants underwent an echo-Doppler exam including 2D global longitudinal strain (GLS) of both ventricles and 3D echocardiographic RV ejection fraction (RVEF). Results: We observed LV diastolic dysfunction in IPF and no-IPF, and LV GLS but not LV EF reduction only in IPF. RV diastolic and RV GLS abnormalities were observed in IPF versus both controls and no-IPF. RV EF did not differ significantly between IPF and no-IPF. DLCO sb and RV GLS were associated in the pooled pulmonary fibrosis population and in the IPF subgroup (β = 0.708, p 0.001), independently of confounders including pulmonary arterial systolic pressure. Conclusion: Our data highlight the unique diagnostic capabilities of GLS in distinguishing early cardiac damage of IPF from no-IPF patients.
机译：背景：左心室（LV）和右心室（RV）功能障碍在特发性肺纤维化（IPF）中识别出来。关于心脏受累的无特发性肺纤维化（NO-IPF）少知晓。可以通过高级超声心动图探索此问题。方法：临床三十三术临床稳定和治疗 - 幼稚纤维化IPF和28例NO-IPF患者，并注册了30名健康对照。排除标准是自身免疫系统性疾病，冠状病，心力衰竭，原发性心肌病，慢性阻塞性肺病，肺栓塞，初级肺动脉高压。通过一氧化碳（DLCO SB）的扩散能力评估肺部损伤。所有参与者都接受了回声多普勒检查，包括脑室和3D超声心动图的2D全局纵向菌株（GLS），以及3D超声心动图RV喷射分数（RVEF）。结果：我们观察到IPF和No-IPF中的LV舒张功能障碍，LV GLS，但仅在IPF中降低了LV GLS。在IPF中观察到RV舒张和RV GLS异常，而不是控制和NO-IPF。 IPF和NO-IPF之间的RV EF没有显着差异。 DLCO SB和RVGLS在合并的肺纤维化群和IPF子组（β= 0.708，P <0.001）中有关，独立于包括肺动脉收缩压。结论：我们的数据突出了从无IPF患者区分IPF的早期心脏损伤的独特诊断功能。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号