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Impact of Having a Planned Additional Operation at Time of Liver Transplant on Graft and Patient Outcomes

机译:在移植物和患者结果时,在肝移植时具有计划额外操作的影响

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Advances in liver transplantation (LT) have allowed for expanded indications and increased surgical complexity. In select cases, additional surgery may be performed at time of LT rather than prior to LT due to the significant risks associated with advanced liver disease. We retrospectively studied the characteristics and outcomes of patients who underwent an additional planned abdominal or cardiac operation at time of LT between 2011–2019. An additional operation (LT+) was defined as a planned operation performed under the same anesthetic as the LT but not directly related to the LT. In total, 547 patients were included in the study, of which 20 underwent LT+ (4%). Additional operations included 10 gastrointestinal, 5 splenic, 3 cardiac, and 2 other abdominal operations. Baseline characteristics between LT and LT+ groups were similar. The median total operating time was significantly longer in LT+ compared to LT only (451 vs. 355 min, p = 0.002). Graft and patient survival, intraoperative blood loss, transfusion of blood products, length of hospital stay, and post-operative complications were not significantly different between groups. In carefully selected patients undergoing LT, certain additional operations performed at the same time appear to be safe with equivalent short-term outcomes and liver graft survival as those undergoing LT alone .
机译:肝移植(LT)的进展允许扩增的适应症和增加的手术复杂性。在选择病例中,由于与晚期肝病相关的显着风险,可以在LT的时间来执行额外的手术,而不是在LT之前进行。我们回顾性研究了在2011 - 2019年在LT之间进行了额外的计划腹部或心脏病的患者的特征和结果。附加操作(LT +)被定义为在与LT的相同但不与LT直接相关的令人垂涎于但不与LT直接相关的计划操作。总共包括547名患者,其中20名患者(其中20名患者)在LT +(4%)之外。附加操作包括10个胃肠道,5个脾,3个心脏和2个其他腹部操作。 LT和LT +组之间的基线特性相似。与LT LT(451 vs.355分钟,P = 0.002)相比,中位总操作时间在LT +中明显更长。贪污和患者存活,术中失血,血液产量输血,住院时间长,以及术后并发症之间的群体之间没有显着差异。在精心挑选的患者中,同时进行的某些额外的操作似乎是安全的等效短期成果和肝移植物存活,因为单独进行的那些。

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