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首页> 外文期刊>Journal of Clinical Medicine >Local Serpin Treatment via Chitosan-Collagen Hydrogel after Spinal Cord Injury Reduces Tissue Damage and Improves Neurologic Function
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Local Serpin Treatment via Chitosan-Collagen Hydrogel after Spinal Cord Injury Reduces Tissue Damage and Improves Neurologic Function

机译：脊髓损伤后通过壳聚糖 - 胶原水凝胶治疗局部蛇治疗减少组织损伤并改善神经系统功能

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Spinal cord injury (SCI) results in massive secondary damage characterized by a prolonged inflammation with phagocytic macrophage invasion and tissue destruction. In prior work, sustained subdural infusion of anti-inflammatory compounds reduced neurological deficits and reduced pro-inflammatory cell invasion at the site of injury leading to improved outcomes. We hypothesized that implantation of a hydrogel loaded with an immune modulating biologic drug, Serp-1, for sustained delivery after crush-induced SCI would have an effective anti-inflammatory and neuroprotective effect. Rats with dorsal column SCI crush injury, implanted with physical chitosan-collagen hydrogels (CCH) had severe granulomatous infiltration at the site of the dorsal column injury, which accumulated excess edema at 28 days post-surgery. More pronounced neuroprotective changes were observed with high dose (100 μg/50 μL) Serp-1 CCH implanted rats, but not with low dose (10 μg/50 μL) Serp-1 CCH. Rats treated with Serp-1 CCH implants also had improved motor function up to 20 days with recovery of neurological deficits attributed to inhibition of inflammation-associated tissue damage. In contrast, prolonged low dose Serp-1 infusion with chitosan did not improve recovery. Intralesional implantation of hydrogel for sustained delivery of the Serp-1 immune modulating biologic offers a neuroprotective treatment of acute SCI.
机译：脊髓损伤（SCI）导致巨大的二次损伤，其特征在于肺纤维癌血栓侵袭和组织破坏的延长炎症。在现有的工作中，抗炎化合物的持续修压抑制性降低了神经缺陷和损伤部位的促炎细胞侵袭降低，导致改善结果。我们假设灌注诱导的SCI后植入载有免疫调节生物药物，Serp-1的水凝胶，用于持续递送将具有有效的抗炎和神经保护作用。植入物理壳聚糖 - 胶原水凝胶（CCH）的背柱SCI压碎损伤的大鼠在背柱损伤的部位进行了严重的肉芽肿性浸润，在手术后28天累积过量水肿。用高剂量（100μg/50μl）Serp-1 CCH植入大鼠观察更明显的神经保护改变，但不具有低剂量（10μg/50μl）Serp-1 CCH。用SERP-1 CCH植入物处理的大鼠还改善了高达20天的电动机功能，归因于抑制炎症相关的组织损伤的神经系统缺陷。相比之下，延长低剂量Serp-1输注壳聚糖不会改善恢复。水凝胶的持续递送SERP-1免疫调节生物学的内部植入提供了对急性SCI的神经保护治疗。

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