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首页> 外文期刊>Journal of Clinical Medicine >Uterus Transplantation with Live Donors: Screening Candidates in One French Center
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Uterus Transplantation with Live Donors: Screening Candidates in One French Center

机译：与现场捐助者的子宫移植：筛选一个法国中心的候选人

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摘要

We report our experience regarding the profile and screening process of potential recipients (R) and their live donors (D) in our Uterus transplantation (UTx) trial from 2014 to 2020. The initial screening was performed using medical questionnaires and consultations. The second step of the screening consisted of two individual interviews with an independent multidisciplinary committee. Then, a complete medical, biological and imaging assessment of the directed living D, the R, and her partner was performed over a two-day hospitalization. A total of 239 women contacted our department: 165 potentials R and 74 potentials D. During the first step of screening, 141 R and 45 D were excluded. Only 12 R/D pairs were pursued. During inclusion, 10 R/D pairs were excluded. One R/D pair is still under evaluation. Finally, only 1 R/D pair was definitively included (0.6%), which led us to perform the first French UTx in March 2019 with a successful graft. The primary limiting factors of inclusion were due to very strict criteria and difficulty of having a suitable directed living D. The International Society of UTx (ISUTx) guidelines based on worldwide results of trials can help ease our inclusion criteria in the future while remaining safe for patients.
机译：我们向2014年至2020年的子宫移植（UTX）试验中潜在受者（R）及其活捐赠者（D）的潜在接受者（r）及其活捐赠者（d）的筛选过程的经验。使用医疗问卷和磋商进行初始筛查。筛查的第二步包括两个与独立多学科委员会的个人访谈。然后，对定向生活D，R和她的伴侣的完整医疗，生物和成像评估是在为期两天的住院期进行的。共有239名妇女联系我们部门：165潜力R和74潜力D.在筛选的第一步，排除了141 r和45d。追求了12次R / D对。在包含期间，排除了10 r / d对。一个R / D对仍在评估中。最后，只有1次R / D对被确定（0.6％），导致我们在2019年3月进行第一个法国UTX，以成功的移植物。纳入的主要限制因素是由于具有合适的指导生活方式的标准和难度的标准和困难。基于全球审判结果的国际UTX（ISUTX）指南的国际社会可以帮助您减轻未来的纳入标准，同时保持安全耐心。

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