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首页> 外文期刊>Journal of Clinical Medicine Research >Angiotensin-Converting Enzyme Gene Polymophism in Adult Primary Focal Segmental Glomerulosclerosis
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Angiotensin-Converting Enzyme Gene Polymophism in Adult Primary Focal Segmental Glomerulosclerosis

机译：血管紧张素转化酶基因多态性在成人初级局灶性细分肾小球粥样硬化

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Background: Primary focal segmental glomerulosclerosis (FSGS) accounts for a third of biopsy-proven primary glomerulonephritis in Malaysia. Pediatric studies have found the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene to be associated with renal disease progression. The aim of this study was to determine the prevalence of the ACE (I/D) genotypes in adult primary FSGS and its association with renal outcome on follow-up. Methods: Prospective observational study involving primary FSGS patients was conducted. Biochemical and urine tests at the time of study were compared to the time of the diagnosis and disease progression analyzed. ACE gene polymorphism was identified using polymerase chain reaction amplification technique and categorized into II, ID and DD genotypes. Results: Forty-five patients with a median follow-up of 3.8 years (interquartile range: 1.8 - 5.6) were recruited. The commonest genotype was II (n = 23, 51.1%) followed by ID (n = 19, 42.2%) and DD (n = 3, 6.7%). The baseline characteristics were comparable between the II and non-II groups at diagnosis and at study recruitment except that the median urine protein-creatinine index was significantly lower in the II group compared to the non-II group (0.02 vs. 0.04 g/mmol (P = 0.03). Regardless of genotypes, all parameters of renal outcome improved after treatment. Conclusion: The II followed by ID genotypes were the predominant ACE gene alleles in our FSGS. Although the D allele has been reported to have a negative impact on renal outcome, treatment appeared to be more important than genotype in preserving renal function in this cohort.J Clin Med Res. 2014;6(4):245-251 doi: http://dx.doi.org/10.14740/jocmr1550w
机译：背景：主要焦检肾小球静脉曲张（FSGS）占马来西亚活检证实的初级肾小球肾炎的三分之一。儿科研究发现了血管紧张素转换酶（ACE）基因的插入/缺失（I / D）多态性与肾病进展相关。本研究的目的是确定成人初级FSGS中ACE（I / D）基因型的患病率及其与随访肾果区的关系。方法：进行涉及初级FSGS患者的前瞻性观察性研究。与分析的诊断和疾病进展的时间进行了比较研究的生化和尿液试验。使用聚合酶链反应扩增技术鉴定ACE基因多态性，并将其分为II，ID和DD基因型。结果：招募了四十五名中位随访3.8岁（间条等：1.8 - 5.6）。最常见的基因型是II（n = 23,51.1％），然后是ID（n = 19,42.2％）和DD（n = 3,6.7％）。在诊断和研究招募的II和非II族之间的基线特征在II组中的中位尿蛋白 - 肌肉酐指数与非II基团相比（0.02与0.04g / mmol相比（P = 0.03）。无论基因型如何，治疗后肾果糖的所有参数都改善。结论：II后跟ID基因型是我们FSGS中的主要ACE基因等位基因。虽然据报道，虽然D等位基因对肾果区，治疗似乎比在这个COHORT.J Clin Med Res中保留肾功能的基因型更重要。2014; 6（4）：245-251 Doi：http：//dx.doi.org/10.14740/jocmr1550w

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