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首页> 外文期刊>Journal of Clinical Medicine Research >Appendicectomy and Clostridium Difficile Infection: Is There a Link?
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Appendicectomy and Clostridium Difficile Infection: Is There a Link?

机译：阑尾切除术和梭菌差异感染：是否有链接？

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Clostridium difficile infection (CDI) is a gradually emerging healthcare problem in the western world, occurring predominantly from the de-arrangement of the gut microbiota and the widespread use of antibiotics. Recently, it has been proposed that the presence or absence of the appendix could be a factor influencing the occurrence and/or the severity of CDI. We performed a review of the literature, aiming to identify and interpret in an accumulative way the results of the published clinical studies which addressed the issue of a possible association between prior appendicectomy and the features of CDI. A total of five suitable studies were retrieved, which were all conducted retrospectively. Although the results were conflicting regarding the impact of prior appendicectomy in the occurrence and relapse of CDI, it appears that the presence or absence of the appendix is not associated with the clinical severity of CDI. Based on the current evidence and considering the effects of the widespread use of antibiotics in the clinical practice, it appears that an in situ appendix does not have a definitive impact on the development and severity of CDI. Further observational studies are warranted to clarify any potential association.J Clin Med Res. 2014;6(4):239-241doi: http://dx.doi.org/10.14740/jocmr1840w
机译：Clostridium艰难的感染（CDI）是西方世界的逐步新兴的医疗问题，主要发生在肠道微生物群的解除安排和抗生素的广泛使用。最近，已经提出了附录的存在或不存在可能是影响CDI的发生和/或严重程度的因素。我们对文献进行了审查，旨在以累计的方式识别和解释公布的临床研究的结果，这些临床研究的结果解决了先前的阑尾切除术和CDI特征之间可能的关联问题。还检索了总共有五项合适的研究，这些研究全部进行了回顾性。虽然结果对先前附录切除术在CDI的发生和复发的影响方面存在矛盾，但似乎附录的存在或不存在与CDI的临床严重程度无关。根据目前的证据，并考虑到临床实践中广泛使用抗生素的影响，似乎是原位附录对CDI的发展和严重程度没有明确的影响。有必要进一步的观察研究来澄清任何潜在的协会.J Clin Med Res。 2014; 6（4）：239-241DOI：http：//dx.doi.org/10.14740/jocmr1840w

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