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首页> 外文期刊>Journal of Clinical Medicine Research >Relation Between Central Venous, Peripheral Venous and Arterial Lactate Levels in Patients With Sepsis in the Emergency Department
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Relation Between Central Venous, Peripheral Venous and Arterial Lactate Levels in Patients With Sepsis in the Emergency Department

机译：急诊部脓毒症患者中央静脉，外周静脉和动脉乳酸水平的关系

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Sepsis and multi-organ failure remain a major clinical problem with high morbidity and mortality worldwide. Lactate measurement remains part of the initial assessment and management of patients with sepsis. Although arterial blood is most commonly used for lactate measurement, there is increasing use of peripheral venous lactate for initial assessment and for monitoring of response to treatment in patients with sepsis. The aim of this study was to evaluate the relation between lactate levels measured from central line, peripheral vein and arterial line in patients treated for sepsis in the emergency department (ED). This prospective study enrolled 31 patients with diagnosis of sepsis who were evaluated and treated in the ED of a university hospital. During initial resuscitation, blood samples from the artery, peripheral vein and central vein (when available) were collected and lactate concentrations were measured. Correlation between lactate values from the three different locations was assessed using Pearson correlation. Bland-Altman plots were used to evaluate agreement between lactate measurements in different sampling locations. All patients were eventually admitted to the Internal Medicine Department ward or to the intensive care unit (ICU) for further treatment. Our data showed strong, highly significant correlation between arterial and peripheral venous lactate levels (r = 0.880, P 0.0001), between arterial and central venous blood lactate (r = 0.898, P 0.0001) and between central and peripheral venous blood lactate (r = 0.941, P 0.0001). In this study we observed strong correlation between arterial, central vein and peripheral vein lactate concentrations in 31 patients assessed and treated for sepsis. We suggest that lactate measurement in peripheral venous blood could be used for screening and for monitoring response to therapy in sepsis patients. However, because this is a small study in only 31 patients and published data are limited, larger studies are needed in order to confirm the validity of our findings.
机译：败血症和多器官衰竭仍然是全球性发病率和死亡率高的主要临床问题。乳酸乳酸测量仍然是败血症患者初步评估和管理的一部分。虽然动脉血最常用于乳酸乳酸测量，但越来越多地使用外周静脉乳酸术进行初步评估，并监测败血症患者治疗的反应。本研究的目的是评估在急诊部（ED）治疗的患者中，从中央线，外周静脉和动脉线测量的乳酸水平之间的关系。该前瞻性研究注册了31例患者诊断，患有在大学医院的ED中进行评估和治疗的败血症。在初始复苏期间，收集来自动脉，外周静脉和中央静脉（当可用时）的血液样品并测量乳酸浓度。使用Pearson相关评估来自三个不同位置的乳酸乳酸盐值之间的相关性。 Bland-Altman情节用于评估不同抽样位置的乳酸测量之间的一致性。所有患者最终都被录取到内部医学部门病房或重症监护室（ICU）进行进一步治疗。我们的数据显示出在动脉和中央静脉血液（R = 0.898，P <0.0001）和中央和外周静脉血液之间（r = 0.898，p <0.0001）之间存在强烈，动脉和周围静脉乳酸水平（r = 0.880，p <0.0001）之间的强烈的相关性r = 0.941，p <0.0001）。在这项研究中，我们观察到动脉，中央静脉和外周静脉乳酸浓度在31例评估和治疗败血症中的患者之间的强烈相关性。我们表明外周血血液中的乳酸乳酸测量可用于筛选和监测对败血症患者治疗的反应。但是，由于这是仅31名患者和公布数据的小型研究有限，因此需要更大的研究，以确认我们的研究结果的有效性。

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