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首页> 外文期刊>Journal of Clinical Medicine Research >Serum Uric Acid, Serum Uric Acid to Serum Creatinine Ratio and Serum Bilirubin in Patients With Parkinson’s Disease: A Case-Control Study
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Serum Uric Acid, Serum Uric Acid to Serum Creatinine Ratio and Serum Bilirubin in Patients With Parkinson’s Disease: A Case-Control Study

机译：患有帕金森病患者的血清尿酸，血清尿酸与血清肌酸酐比和血清胆红素：一个病例对照研究

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Background:Studies have shown that a low serum uric acid (SUA) level associates with Parkinson's disease (PD), but many of them did not exclude patients with impaired renal function. Studies on the association between serum bilirubin level and PD also are limited. This study determined the association between SUA level, SUA/serum creatinine (SCr) ratio and serum bilirubin levels in PD patients with normal renal and liver functions.Methods:The PD patients from a neurological clinic, and the controls from the club for the elderly, were recruited into this study. The PD stage and motor and non-motor function were determined by the Hoehn-Yahr (H&Y) scale and unified Parkinson's disease rating scale (UPDRS), respectively.Results:Sixty-one PD patients and 135 controls participated. The SUA/SCr ratio, but not SUA, was significantly lower in the PD patients than in the controls (4.12 ± 0.90 vs. 4.59 ± 1.04, P = 0.003). Serum total bilirubin (TB) and indirect bilirubin (IDB) were significantly higher in the PD patients (7.92 ± 3.67 μmol/L vs. 6.59 ± 2.78 μmol/L, P = 0.003 and 4.52 ± 2.48 μmol/L vs. 3.26 ± 1.82 μmol/L, P 0.001), respectively. Serum TB and IDB, but not SUA or SUA/SCr ratio, were associated negatively with PD stages (P = 0.010 and P = 0.014, respectively). There was no association between TB, IDB, SUA or SUA/SCr ratio and PD disease duration or motor subtypes. No significant correlation was found between SUA or SUA/SCr ratio, serum TB and IDB.Conclusion:The SUA/SCr ratio is more sensitive than SUA in determining their association with PD. The high serum TB and IDB levels in PD patients compared with the controls suggest that serum bilirubin might play a role in the pathogenesis of PD. However, the lack of association between SUA or the SUA/SCr ratio and serum TB or IDB suggests that these two biomarkers play a different role in the etiopathogenesis of PD.Copyright 2020, Songsomboon et al.
机译：背景：研究表明，低血清尿酸（SUA）水平与帕金森病（PD）辅助，但其中许多并未排除肾功能受损的患者。关于血清胆红素水平和PD之间的关联的研究也有限。该研究确定了SUA水平，SUA /血清肌酐（SCR）比和PD患者患者癌症和肝功能的血清胆红素水平之间的关联。方法：来自神经诊所的PD患者，以及老年人的俱乐部控制，被招募了这项研究。 PD阶段和电动机和非运动功能分别由Hoehn-yahr（H＆Y）规模和统一的帕金森病评级规模（UPDRS）确定。结果：参加了60名PD患者和135名控股。 PD患者的SUA / SCR比例但不是SUA显着低于对照（4.12±0.90与4.59±1.04，P = 0.003）。 PD患者血清总胆红素（TB）和间接胆红素（IDB）显着高于6.92±3.67μmol/ L.6.59±2.78μmol/ L，P = 0.003和4.52±2.48μmol/ L与3.26±1.82 μmol/ l，p <0.001）。血清TB和IDB，但不是SUA或SUA / SCR比率与PD阶段负相关（分别为P = 0.010和P = 0.014）。 TB，IDB，SUA或SUA / SCR比率和PD疾病持续时间或电机亚型之间没有关联。 SUA或SUA / SC / SCR比率没有显着的相关性，血清TB和IDB。结论：SUA / SCR比比SUA更敏感，在确定其与PD的关联时。 PD患者的高血清TB和IDB水平与对照相比表明，血清胆红素可能在PD的发病机制中发挥作用。然而，SUA或SUA / SCR比和血清TB或IDB之间的关联缺乏相关性认为，这两个生物标志物在PD.Copyright 2020，Songsomboon等人的病原体中发挥着不同的作用。

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