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首页> 外文期刊>Journal of Clinical Medicine Research >Association Between Low Vitamin D Levels and the Greater Impact of Fibromyalgia
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Association Between Low Vitamin D Levels and the Greater Impact of Fibromyalgia

机译：低维生素D水平与纤维肌痛的影响较大

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Background:Fibromyalgia (FM) is a clinical syndrome mainly characterized by generalized chronic pain, fatigue, sleep and cognition disorders. The role played by vitamin D in the pathophysiology of painful syndromes is poorly known. Studies assessing the association between vitamin D and FM have presented conflicting results. The aims of the current study were to assess vitamin D levels in FM patients, by comparing them to healthy controls, as well as to analyze their impact on this disease.Methods:This was a cross-sectional study comprising 43 FM patients (ACR 2010 criteria) and 40 healthy individuals. All participants had their vitamin D levels measured, and FM patients also had their total calcium, albumin, phosphorus and parathyroid hormone (PTH) measured. Clinical variables capable of affecting the results were evaluated and the fibromyalgia impact questionnaire (FIQ) was applied.Results:There was not statistically significant difference in global mean values of vitamin D between groups. In the total sample, only 4.8% of the individuals had vitamin D deficiency, which corresponded to the deficiency found in the group of patients; in the control, no one had vitamin deficiency; 39.8% had insufficient levels and 55.4% with sufficient levels. The mean serum vitamin D values were similar between the FM and control groups (34.8 ± 12 and 34.7 ± 12.3 ng/mL, respectively; P = 0.806). However, a significant negative correlation was found between vitamin D concentration and FIQ values, that is, patients with the greatest impact of the disease had lower concentrations of vitamin D (P = 0.018).Conclusion:FM patients did not present higher prevalence of vitamin D deficiency or insufficiency than healthy individuals, although low vitamin D concentrations could indicate more severe disease impacts.Copyright 2020, Beserra et al.
机译：背景：纤维肌痛（FM）是一种临床综合征，其特征在于广义慢性疼痛，疲劳，睡眠和认知障碍。维生素D在痛苦综合征病理生理学中发挥的作用是众所周知的。评估维生素D和FM之间关联的研究表现出相互矛盾的结果。目前的研究的目的是通过将它们与健康对照进行比较来评估FM患者的维生素D水平，以及分析它们对该疾病的影响。方法：这是包含43名FM患者的横断面研究（AC10标准）和40个健康的个人。所有参与者都有他们的维生素D水平测量，FM患者还具有其总钙，白蛋白，磷和甲状旁腺激素（PTH）测量。评估能够影响结果的临床变量，并施加纤维肌痛调查问卷（FIQ）。结果：组中的全局平均值没有统计学意义。在总样品中，只有4.8％的个体具有维生素D缺乏症，其与患者组中发现的缺乏相对应;在控制中，没有人患有维生素缺乏; 39.8％的水平不足，55.4％，水平足够。平均血清维生素D值在FM和对照组之间类似（34.8±12和34.7±12.3ng / ml; P = 0.806）。然而，在维生素D浓度和FIQ值之间发现了显着的负相关，即疾病影响最大的患者具有较低的维生素D浓度（P = 0.018）。结论：FM患者对维生素的患病率较高D缺乏或不足，虽然低维生素D浓度可能表明更严重的疾病影响。2020，Beserrra等。

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