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首页> 外文期刊>Journal of Clinical Medicine Research >Non-Alcoholic Fatty Liver Disease Modifies Serum Gamma-Glutamyl Transferase in Cigarette Smokers
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Non-Alcoholic Fatty Liver Disease Modifies Serum Gamma-Glutamyl Transferase in Cigarette Smokers

机译：非酒精脂肪肝疾病在吸烟者中改变血清γ-戊二醇转移酶

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Background: Serum gamma-glutamyl transferase (GGT) is a marker of oxidative stress, associated with increased cardiovascular (CV) risk. The impact of smoking on oxidative stress may be aggravated in individuals with non-alcoholic fatty liver disease (NAFLD). We aimed to ascertain the association of smoking on GGT levels in the presence or absence of NAFLD. Methods: We evaluated 6,354 healthy subjects (43 ± 10 years, 79% males) without clinical cardiovascular disease (CVD) undergoing an employer-sponsored physical between December 2008 and December 2010. NAFLD was diagnosed by ultrasound and participants were categorized as current or non-smokers by self report. A multivariate linear regression of the cross-sectional association between smoking and GGT was conducted based on NAFLD status. Results: The prevalence of NAFLD was 36% (n = 2,299) and 564 (9%) were current smokers. Smokers had significantly higher GGT levels in the presence of NAFLD (P 0.001). After multivariable adjustment, current smoking was associated with 4.65 IU/L higher GGT level, P 0.001, compared to non-smokers. When stratified by NAFLD, the magnitude of this association was higher in subjects with NAFLD (β-coefficient: 11.12; 95% confidence interval (CI): 5.76 - 16.48; P 0.001); however, no such relationship was observed in those without NAFLD (β: -0.02; 95% CI: -3.59, 3.56; P = 0.992). Overall the interaction of NAFLD and smoking with GGT levels as markers of oxidative stress was statistically significant. Conclusions: Smoking is independently associated with significantly increased oxidative stress as measured by GGT level. This association demonstrates effect modification by NAFLD status, suggesting that smoking may intensify CV risk in individuals with NAFLD.
机译：背景：血清γ-戊二酰转移酶（GGT）是氧化应激的标志物，与心血管（CV）风险增加相关。吸烟对氧化应激的影响可能在具有非酒精脂肪肝病（NAFLD）的个体中加剧。我们的旨在确定在NAFLD的存在或不存在中对GGT水平吸烟的协会。方法：我们评估了6,354名健康受试者（43±10年，79％的男性），没有临床心血管疾病（CVD）在2008年12月和2010年12月之间进行雇主赞助的身体。通过超声波诊断，参与者被诊断为当前或非 - 自我报告的摩托车。基于NAFLD状态进行了吸烟和GGT之间的横截面关联的多变量线性回归。结果：NAFLD的患病率为36％（n = 2,299），564（9％）是目前吸烟者。在NAFLD存在下，吸烟者的GGT水平显着增加（P <0.001）。经过多变量调节后，与非吸烟者相比，目前吸烟与4.65 IU / L较高的GGT水平，P <0.001相关。当由NAFLD分层时，NAFLD的受试者（β-系数：11.12; 95％置信区间（CI）：5.76-16.48; P <0.001）中，这种关联的大小更高。然而，在没有NAFLD的那些中没有观察到这种关系（β：-0.02; 95％CI：-3.59,3.56; p = 0.992）。总体而言，NAFLD与GGT水平吸烟的相互作用作为氧化胁迫标记的统计学意义。结论：通过GGT水平测量的氧化胁迫显着增加，吸烟独立相关。该关联证明了NAFLD地位的效果改性，表明吸烟可能会加剧NAFLD个人中的CV风险。

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