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首页> 外文期刊>Journal of Clinical Sciences >Evaluation of prophylactic intravenous hydrocortisone for the prevention of postdural puncture headache following spinal anesthesia for cesarean section
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Evaluation of prophylactic intravenous hydrocortisone for the prevention of postdural puncture headache following spinal anesthesia for cesarean section

机译：剖宫产后脊髓麻醉后预防预防静脉氢化胞酮的评价

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Context: Postdural puncture headache (PDPH) is a common complication following spinal anesthesia. No medication is currently used on routine basis for its prevention despite its high incidence. Aims: This study evaluated the efficacy of prophylactic intravenous (IV) hydrocortisone 100 mg in reducing the incidence and severity of PDPH among obstetric patients who had spinal anesthesia for cesarean delivery. Study Design: This study is a double-blind, randomized controlled trial in which 400 consenting parturients having cesarean section under spinal anesthesia were randomized into two groups; hydrocortisone and control groups. Following delivery, patients in the hydrocortisone group received IV hydrocortisone 100 mg diluted to 2 ml while those in the control group received the same volume of 0.9% saline. Patients were reviewed for the occurrence of PDPH over 5 days and headache severity assessed using the numerical rating scale. Intraoperative and postoperative side effects of single-dose hydrocortisone were also documented. Statistical Analysis: Data were analyzed using SPSS 20 software. A P 0.05 was considered statistically significant. Results: A total of 197 and 194 patients completed the study in the hydrocortisone and control groups, respectively. In the hydrocortisone group, 46 patients (23.4%) developed PDPH compared to 48 patients (24.7%) in the control group (P = 0.813). Both the mean maximum NRS scores as well as headache severity grades were similar between both groups with P = 0.930 and 0.714, respectively. The duration of PDPH averaged 2.87 ± 1.44 days in hydrocortisone group compared with 2.73 ± 1.38 days in control group (P = 0.630). Conclusions: Prophylactic IV hydrocortisone 100 mg does not reduce the incidence or severity of PDPH following spinal anesthesia for cesarean section.
机译：背景：后宫穿刺头痛（PDPH）是脊髓麻醉后的常见并发症。尽管其发病率高，但目前没有药物目前用于预防常规。目的：本研究评估了预防性静脉内（IV）氢化可的松100mg对患有脊髓麻醉的产科患者PDPH的发病率和严重程度的疗效。研究设计：本研究是一种双盲，随机对照试验，其中400个在脊髓麻醉下具有剖宫产的剖腹产分为两组;氢化体和对照组。递送后，氢化可源酮基团的患者接受稀释至2mL的IV氢化可的100mg，而对照组的那些在相同体积的0.9％盐水中。患者被审查了PDPH的发生超过5天，并且使用数值评定量表评估的头痛严重程度。还记录了单剂量氢化胞质的术中和术后副作用。统计分析：使用SPSS 20软件进行分析数据。 P <0.05被认为是统计学意义的。结果：共有197例和194名患者分别完成了氢化可的松和对照组的研究。在氢化鞘酮组中，46名患者（23.4％）发育的PDPH与48名患者（24.7％）（P = 0.813）。两个组之间的平均最大NRS分数以及P = 0.930和0.714的两组之间都相似。氢化可源性基团Pdph的持续时间平均为2.87±1.44天，与对照组的2.73±1.38天相比（p = 0.630）。结论：预防IV氢化可酮100mg不会降低剖宫产后脊髓麻醉后P.PPPH的发病率或严重程度。

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